The microstructural status of the corpus callosum is associated with the degree of motor function and neurological deficit in stroke patients.
The microstructural status of the corpus callosum is associated with the degree of motor function and neurological deficit in stroke patients.
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DOI：
10.1371/journal.pone.0122615
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Li Y;Wu P;Liang F;Huang W
人类神经影像学研究和动物模型表明，缺血性卒中引起的白色物质损伤导致病灶周围和远端脑区的功能和结构重组。然而，脑卒中后经胼胝体束完整性与临床运动表现评分之间的定量关系尚未探讨。本研究采用基于束的空间统计（TBSS）分析扩散张量成像（DTI），探讨脑卒中患者白色扩散率变化与临床评分之间的关系。概率纤维追踪也被用于识别患者的结构连接模式。13名缺血性卒中患者和15名健康对照受试者参加了这项研究。TBSS分析显示，与对照组相比，脑卒中患者胼胝体（CC）和双侧皮质脊髓束（CST）的各向异性分数显著降低，轴向和径向扩散系数显著增加。相关性分析显示，脑卒中患者的运动和神经功能缺损评分与CC的弥散指数值相关。与健康对照组比较，概率纤维追踪分析显示，脑卒中患者左右侧运动皮质间纤维联系的显著改变主要位于CC的前、体部、左侧丘脑前放射束和额枕下束、双侧CST、前/上级放射冠、扣带回和上级纵束，这强烈地表明缺血诱导半球间网络紊乱并破坏连接运动区的白色纤维。总之，本研究的结果表明，DTI衍生的措施，在CC可以用来预测中风患者的运动技能和神经功能缺损的严重程度。左右运动区之间的结构连接模式跟踪的变化，特别是在身体的CC，可能反映了功能重组和行为缺陷。
Human neuroimaging studies and animal models have suggested that white matter damage from ischemic stroke leads to the functional and structural reorganization of perilesional and remote brain regions. However, the quantitative relationship between the transcallosal tract integrity and clinical motor performance score after stroke remains unexplored. The current study employed a tract-based spatial statistics (TBSS) analysis on diffusion tensor imaging (DTI) to investigate the relationship between white matter diffusivity changes and the clinical scores in stroke patients. Probabilistic fiber tracking was also used to identify structural connectivity patterns in the patients. Thirteen ischemic stroke patients and fifteen healthy control subjects participated in this study. TBSS analyses showed that the corpus callosum (CC) and bilateral corticospinal tracts (CST) in the stroke patients exhibited significantly decreased fractional anisotropy and increased axial and radial diffusivity compared with those of the controls. Correlation analyses revealed that the motor and neurological deficit scores in the stroke patients were associated with the value of diffusivity indices in the CC. Compared with the healthy control group, probabilistic fiber tracking analyses revealed that significant changes in the inter-hemispheric fiber connections between the left and right motor cortex in the stroke patients were primarily located in the genu and body of the CC, left anterior thalamic radiation and inferior fronto-occipital fasciculus, bilateral CST, anterior/superior corona radiate, cingulum and superior longitudinal fasciculus, strongly suggesting that ischemic induces inter-hemispheric network disturbances and disrupts the white matter fibers connecting motor regions. In conclusion, the results of the present study show that DTI-derived measures in the CC can be used to predict the severity of motor skill and neurological deficit in stroke patients. Changes in structural connectivity pattern tracking between the left and right motor areas, particularly in the body of the CC, might reflect functional reorganization and behavioral deficit.
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DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
DOI：
10.1523/jneurosci.3923-07.2007
发表时间：
2007-10-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Grol MJ;Majdandzić J;Stephan KE;Verhagen L;Dijkerman HC;Bekkering H;Verstraten FA;Toni I
通讯作者：
Toni I
影响因子：
5.7
作者：
Borich, Michael R.;Wadden, Katie P.;Boyd, Lara A.
通讯作者：
Boyd, Lara A.
影响因子：
14.5
作者：
FRIES, W;DANEK, A;HAMBURGER, C
通讯作者：
HAMBURGER, C
影响因子：
8.3
作者：
Bhadelia RA;Price LL;Tedesco KL;Scott T;Qiu WQ;Patz S;Folstein M;Rosenberg I;Caplan LR;Bergethon P
通讯作者：
Bergethon P