Interplay between Solid Tumors and Tumor Microenvironment.
Interplay between Solid Tumors and Tumor Microenvironment.
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实体肿瘤与肿瘤微环境的相互作用。
DOI：
10.3389/fimmu.2022.882718
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
在过去的几十年里，旨在治愈癌症患者的基础研究一直在不断发展。已有大量关于肿瘤生长和转移的生理变化及其相关因素的机制研究报道。最近，一些研究已经考虑了肿瘤如何适应不利的环境，如葡萄糖剥夺、氧化应激、低氧条件和免疫反应。肿瘤试图通过遗传或非遗传变化、代谢信号的改变或通过迁移到其他器官来重新配置其环境来适应不利的环境。实体瘤的一个显著特征是异质性，因为它们的环境因菌落生长的特点而不同。出于这个原因，研究人员正在关注生长中的肿瘤与周围环境之间的沟通，包括基质细胞、免疫细胞、成纤维细胞以及分泌的分子，如蛋白质和RNA。在肿瘤的生存和发展过程中，肿瘤细胞经历了被统称为细胞可塑性的表型和分子变化，这些变化是微环境信号、遗传学和表观遗传学改变的结果，从而促进了肿瘤的异质性和治疗反应。在这篇综述中，我们讨论了肿瘤通过与邻近细胞的沟通来适应不利环境的过程，以克服不利的生长条件。了解这些肿瘤的生理机制以及它们与肿瘤环境的联系有助于开发有前景的肿瘤治疗策略。
Over the past few decades, basic studies aimed at curing patients with cancer have been constantly evolving. A myriad of mechanistic studies on physiological changes and related factors in tumor growth and metastasis have been reported. Recently, several studies have been considerate to how tumors adapt to unfavorable environments, such as glucose deprivation, oxidative stress, hypoxic conditions, and immune responses. Tumors attempt to adapt to unfavorable environments with genetic or non-genetic changes, the alteration of metabolic signals, or the reconfiguration of their environment through migration to other organs. One of the distinct features in solid tumors is heterogeneity because their environments vary due to the characteristics of colony growth. For this reason, researchers are paying attention to the communication between growing tumors and neighboring environments, including stromal cells, immune cells, fibroblasts, and secreted molecules, such as proteins and RNAs. During cancer survival and progression, tumor cells undergo phenotype and molecular changes collectively referred to as cellular plasticity, which result from microenvironment signals, genetics and epigenetic alterations thereby contributing to tumor heterogeneity and therapy response. In this review, we herein discuss the adaptation process of tumors to adverse environments via communication with neighboring cells for overcoming unfavorable growth conditions. Understanding the physiology of these tumors and their communication with the tumor environment can help to develop promising tumor treatment strategies.
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DOI：
10.1186/s13058-016-0740-2
发表时间：
2016-08-11
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bussard KM;Mutkus L;Stumpf K;Gomez-Manzano C;Marini FC
通讯作者：
Marini FC
影响因子：
3.5
作者：
Hill, Richard P.;Marie-Egyptienne, Delphine T.;Hedley, David W.
通讯作者：
Hedley, David W.
影响因子：
5.4
作者：
Blanco, Raquel;Gerhardt, Holger
通讯作者：
Gerhardt, Holger
影响因子：
28.2
作者：
Elyada, Ela;Bolisetty, Mohan;Tuveson, David A.
通讯作者：
Tuveson, David A.
影响因子：
4.7
作者：
Arora L;Pal D
通讯作者：
Pal D