Fine particulate air pollution is associated with higher vulnerability to atrial fibrillation--the APACR study.
Fine particulate air pollution is associated with higher vulnerability to atrial fibrillation--the APACR study.
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DOI：
10.1080/15287394.2011.556056
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cascio WE
中科院分区：
文献类型：
--
作者：
Liao D;Shaffer ML;He F;Rodriguez-Colon S;Wu R;Whitsel EA;Bixler EO;Cascio WE
在社区居住的 106 名非吸烟者样本中，研究了细颗粒物污染 (PM2.5) 对心房颤动/扑动 (AF) 预测因子（包括 P 波持续时间、PR 间期持续时间和 P 波复杂性）的急性影响和时间进程。对个体水平的 24 小时逐次心电图 (ECG) 数据进行目视检查。识别并消除伪影和心律失常后，计算 AF 预测因子的 30 分钟平均值。使用个人 PM2.5 监测仪测量同一 24 小时内个人水平的实时 PM2.5 暴露量，并计算相应的 30 分钟平均 PM2.5 浓度。在线性混合效应建模框架下，使用分布式滞后模型来估计将 PM2.5 与 AF 预测因子相关联的回归系数 (β)。大多数对 AF 预测因子的不利影响发生在 PM2.5 暴露后 1.5-2 小时内。滞后 1 和滞后 2 时 PM2.5 每上升 10 µg/m3 的多变量调整 βs 与 P 波复杂性显着相关。 PM2.5 暴露还与滞后 3 和滞后 4 时的 PR 持续时间延长显着相关。发现较高的 PM2.5 与 P 波复杂性和 PR 持续时间的增加相关。 2 小时内观察到最大效果。这些发现表明 PM2.5 对 AF 预测因子产生不利影响；因此，PM2.5 可能表明更容易发生房颤。
The acute effects and the time course of fine particulate pollution (PM2.5) on atrial fibrillation/flutter (AF) predictors, including P-wave duration, PR interval duration, and P-wave complexity, were investigated in a community-dwelling sample of 106 nonsmokers. Individual-level 24-h beat-to-beat electrocardiogram (ECG) data were visually examined. After identifying and removing artifacts and arrhythmic beats, the 30-min averages of the AF predictors were calculated. A personal PM2.5 monitor was used to measure individual-level, real-time PM2.5 exposures during the same 24-h period, and corresponding 30-min average PM2.5 concentration were calculated. Under a linear mixed-effects modeling framework, distributed lag models were used to estimate regression coefficients (βs) associating PM2.5 with AF predictors. Most of the adverse effects on AF predictors occurred within 1.5–2 h after PM2.5 exposure. The multivariable adjusted βs per 10-µg/m3 rise in PM2.5 at lag 1 and lag 2 were significantly associated with P-wave complexity. PM2.5 exposure was also significantly associated with prolonged PR duration at lag 3 and lag 4. Higher PM2.5 was found to be associated with increases in P-wave complexity and PR duration. Maximal effects were observed within 2 h. These findings suggest that PM2.5 adversely affects AF predictors; thus, PM2.5 may be indicative of greater susceptibility to AF.
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DOI：
10.1097/ede.0b013e3181812bb7
发表时间：
2008-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Franklin M;Koutrakis P;Schwartz P
通讯作者：
Schwartz P
影响因子：
4.5
作者：
通讯作者：
--
影响因子：
6.1
作者：
ALMON, S
通讯作者：
ALMON, S
影响因子：
1.9
作者：
LAIRD, NM;WARE, JH
通讯作者：
WARE, JH
影响因子：
3.8
作者：
Hazari, Mehdi S.;Haykal-Coates, Najwa;Farraj, Aimen K.
通讯作者：
Farraj, Aimen K.