Individual-level PM₂.₅ exposure and the time course of impaired heart rate variability: the APACR Study.
Individual-level PM₂.₅ exposure and the time course of impaired heart rate variability: the APACR Study.
复制标题
DOI：
10.1038/jes.2010.21
复制
发表时间：
2011-01
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
我们在106名社区居住的中年非吸烟者中研究了细颗粒物（PM2.5）对心率变异性（HRV）的时间过程和急性影响，心率变异性可测量心脏自主调节（CAM）。24-目视检查24小时逐搏ECG数据。去除了伪影和心跳。采用正常心率数据计算心率变异性指标。个人PM2.5散射比浊法用于估计24小时个人水平的实时PM2.5暴露。我们使用线性混合效应模型来评估PM2.5和HRV指数的1-6小时移动平均值之间的自相关和其他主要混淆因素调整的回归系数。PM2.5的前1-6小时移动平均值的增加与较低的HF，LF和SDNN显著相关，其中4-6小时移动平均值的影响最大，1小时移动平均值的影响最小。例如，1小时和6小时移动平均值增加10 μg/m3分别与log-HF减少0.027和0.068 ms 2相关，分别与log-LF减少0.024和0.071 ms 2相关，分别与SDNN减少0.81和1.75 ms相关（所有p值< 0.05）。PM2.5暴露与CAM的直接损害有关。在PM2.5升高后6小时内出现时间过程，最大影响约为4-6小时。
We examined, in 106 community-dwelling middle-aged non-smokers, the time-course and the acute effects of fine particles (PM2.5) on heart rate variability (HRV), which measures cardiac autonomic modulation (CAM). 24-hour beat-to-beat ECG data were visually examined. Artifacts and arrhythmic beats were removed. Normal beat-to-beat RR data were used to calculate HRV indices. Personal PM2.5 nephelometry was used to estimate 24-hour individual-level real-time PM2.5 exposures. We use linear mixed-effects models to assess autocorrelation- and other major confounder-adjusted regression coefficients between 1-6 hour moving averages of PM2.5 and HRV indices. The increases in preceding 1-6 hour moving averages of PM2.5 was significantly associated with lower HF, LF, and SDNN, with the largest effect size at 4-6 hour moving averages and smallest effects size at 1 hour moving average. For example, a 10 μg/m3 increase in 1-hour and 6-hour moving averages was associated with 0.027 and 0.068 ms2 decrease in log-HF, respectively, and with 0.024 and 0.071 ms2 decrease in log-LF, respectively, and with 0.81 and 1.75 ms decrease in SDNN, respectively (all p values < 0.05). PM2.5 exposures are associated with immediate impairment of CAM. With a time-course of within 6 hours after elevated PM2.5 exposure, with the largest effects around 4-6 hours.
登录
查看更多内容
影响因子：
10.4
作者：
de Hartog, Jeroen J.;Lanki, Timo;Timonen, Kirsi L.;Hoek, Gerard;Janssen, Nicole A. H.;Ibald-Mulli, Angela;Peters, Annette;Heinrich, Joachim;Tarkiainen, Tuula H.;van Grieken, Rene;van Wijnen, Joop H.;Brunekreef, Bert;Pekkanen, Juha
通讯作者：
Pekkanen, Juha
影响因子：
5.4
作者：
Holguin, F;Téllez-Rojo, MM;Romieu, I
通讯作者：
Romieu, I
影响因子：
10.4
作者：
Liao, DP;Creason, J;Zweidinger, R
通讯作者：
Zweidinger, R
影响因子：
37.8
作者：
Magari, SR;Hauser, R;Christiani, DC
通讯作者：
Christiani, DC
DOI：
10.1080/15287390802445483
发表时间：
2009-01-01
影响因子：
2.6
作者：
Liao, Duanping;Whitsel, Eric A.;Anderson, Garnet
通讯作者：
Anderson, Garnet