RNA structure: the long and the short of it.
RNA structure: the long and the short of it.
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DOI：
10.1016/j.sbi.2005.04.005
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发表时间：
2005-06
影响因子：
6.8
通讯作者：
Holbrook SR
中科院分区：
文献类型：
--
作者：
Holbrook SR
自2000-2001年核糖体亚基晶体结构分析以来，RNA结构数据库得到了极大的发展。在过去的一年中，确定大的，复杂的生物RNA的结构的趋势已经加速，与三个完整的I组内含子，A型和B型核糖核酸酶P RNA，核糖开关底物复合物和其他结构的分析。不断增长的RNA结构数据库，加上致力于命名和分类的标准化，导致了许多RNA二级和三级结构基序的鉴定和表征。由于现在可以证明大部分RNA结构是由这些重复的结构基序组成的，因此将RNA视为由这些构建块和三级接头组合而成的模块结构的观点开始出现。然而，与此同时，对水、金属、配体和蛋白质与RNA结合的更详细的分析揭示了这些部分对折叠和结构形成的影响。RNA结构的观点之间的平衡，无论是作为严格的预制构件连接在有限数量的方式或作为一个灵活的聚合物，假设其环境的影响，全球折叠将是当前和未来的RNA结构生物学的焦点。
The database of RNA structure has grown tremendously since the crystal structure analyses of ribosomal subunits in 2000–2001. During the past year, the trend toward determining the structure of large, complex biological RNAs has accelerated, with the analysis of three intact group I introns, A- and B-type ribonuclease P RNAs, a riboswitch–substrate complex and other structures. The growing database of RNA structures, coupled with efforts directed at the standardization of nomenclature and classification of motifs, has resulted in the identification and characterization of numerous RNA secondary and tertiary structure motifs. Because a large proportion of RNA structure can now be shown to be composed of these recurring structural motifs, a view of RNA as a modular structure built from a combination of these building blocks and tertiary linkers is beginning to emerge. At the same time, however, more detailed analysis of water, metal, ligand and protein binding to RNA is revealing the effect of these moieties on folding and structure formation. The balance between the views of RNA structure either as strictly a construct of preformed building blocks linked in a limited number of ways or as a flexible polymer assuming a global fold influenced by its environment will be the focus of current and future RNA structural biology.
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