DNA methylation dynamics during germline development.
DNA methylation dynamics during germline development.
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DOI：
10.1111/jipb.13422
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发表时间：
2022-12
影响因子：
11.4
通讯作者：
中科院分区：
文献类型：
--
作者：
DNA甲基化在真核生物基因组中起着重要的稳态功能。在动物中，DNA甲基化也受到发育调控，反过来又调控发育。在过去的二十年里，大量的研究工作已经证实了DNA甲基化在植物发育中起着类似的作用，特别是在有性生殖过程中。全基因组测序和细胞分离技术以及生物信息学工具的强大功能使最近的研究能够揭示生殖系发育过程中DNA甲基化的动态变化。此外，这些技术进步与遗传学、发育生物学和细胞生物学工具的结合揭示了控制开花植物生殖系中基因和转座子活性的功能性甲基化重编程事件。在这篇综述中，我们讨论了我们的知识在开花植物的雄性和雌性生殖系发育过程中的DNA甲基化动态的主要进展。在表观基因组测序和细胞分离技术的支持下，最近的研究极大地推进了我们对植物生殖表观遗传学的理解。本文综述了植物生殖过程中DNA甲基化动态的主要进展，强调甲基化重编程事件，控制基因和转座子在生殖细胞的活动。
DNA methylation plays essential homeostatic functions in eukaryotic genomes. In animals, DNA methylation is also developmentally regulated and, in turn, regulates development. In the past two decades, huge research effort has endorsed the understanding that DNA methylation plays a similar role in plant development, especially during sexual reproduction. The power of whole‐genome sequencing and cell isolation techniques, as well as bioinformatics tools, have enabled recent studies to reveal dynamic changes in DNA methylation during germline development. Furthermore, the combination of these technological advances with genetics, developmental biology and cell biology tools has revealed functional methylation reprogramming events that control gene and transposon activities in flowering plant germlines. In this review, we discuss the major advances in our knowledge of DNA methylation dynamics during male and female germline development in flowering plants. Powered by epigenomic sequencing and cell isolation techniques, recent research has greatly advanced our understanding of plant reproductive epigenetics. This review discusses the major advances in our knowledge of DNA methylation dynamics during plant reproduction, emphasizing methylation reprogramming events that control gene and transposon activities in the germline.
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影响因子：
7.7
作者：
Borg M;Papareddy RK;Dombey R;Axelsson E;Nodine MD;Twell D;Berger F
通讯作者：
Berger F
影响因子：
7.7
作者：
Dubin MJ;Zhang P;Meng D;Remigereau MS;Osborne EJ;Paolo Casale F;Drewe P;Kahles A;Jean G;Vilhjálmsson B;Jagoda J;Irez S;Voronin V;Song Q;Long Q;Rätsch G;Stegle O;Clark RM;Nordborg M
通讯作者：
Nordborg M
影响因子：
9.5
作者：
Bauer MJ;Fischer RL
通讯作者：
Fischer RL
影响因子：
64.5
作者：
Calarco JP;Borges F;Donoghue MT;Van Ex F;Jullien PE;Lopes T;Gardner R;Berger F;Feijó JA;Becker JD;Martienssen RA
通讯作者：
Martienssen RA
影响因子：
5.1
作者：
Borges, Filipe;Gardner, Rui;Becker, Joerg D.
通讯作者：
Becker, Joerg D.