Genome demethylation and imprinting in the endosperm.

Genome demethylation and imprinting in the endosperm.
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DOI:
10.1016/j.pbi.2011.02.006
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发表时间:
2011-04
影响因子:
9.5
通讯作者:
Fischer RL
Fischer RL
中科院分区:
生物学2区
文献类型:
--
作者:
Bauer MJ;Fischer RL

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印迹发生在开花植物的胚乳中。胚乳是中央细胞受精的产物,对胚和种子的发育至关重要。胚乳中的印记主要是由于配子表观遗传组成的遗传差异。研究还表明,胚和胚乳的基因组DNA甲基化模式存在差异。检查这些差异,沿着DNA去甲基化酶基因DEMETER的突变,可以深入了解印记基因的数量,以及TE防御和基因调控之间的拮抗关系如何在进化上影响印记的建立。最后,研究表明DEMETER脱甲基酶活性影响胚乳染色质组成,并可能增强DNA从头甲基化活性。
Imprinting occurs in the endosperm of flowering plants. The endosperm, a product of central cell fertilization, is critical for embryo and seed development. Imprinting in the endosperm is mainly due to the inherited differences in gamete epigenetic composition. Studies have also shown that there are differences in genomic DNA methylation patterns between embryo and endosperm. Examining those differences, along with mutations in the DNA demethylase gene DEMETER, gives insight into the number of imprinted genes and how an antagonistic relationship between TE defense and gene regulation could evolutionarily affect imprinting establishment. Finally, studies demonstrate that DEMETER demethylase activity influences endosperm chromatin composition, and could possibly enhance DNA de novo methylation activity.
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