Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint.
Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint.
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DOI：
10.1016/j.coi.2009.12.006
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发表时间：
2010-04
影响因子：
7
通讯作者：
von Boehmer H
中科院分区：
文献类型：
--
作者：
Kreslavsky T;Gleimer M;von Boehmer H
αβ和γδ T细胞在胸腺中从共同的前体发育。尽管谱系最初由它们表达的TCR类型定义，但很快就清楚了TCR类型本身在谱系决定中不起决定性作用，因为在各种转基因和敲除模型中，以及在wt小鼠中的一小部分细胞中，TCRγδ可以驱动αβ谱系细胞的分化，而TCRαβ可以驱动γδ谱系细胞的分化。因此，直到最近，人们还不清楚是什么决定了血统的选择，以及两个血统在哪个阶段出现分歧。最近的观察表明，TCR信号强度决定谱系命运，并且谱系选择在第一个TCR控制的检查点时或之后不久做出。虽然清楚的是，αβ和γδ谱系之间的决定是在第一个TCR控制的检查点做出的，并且αβ亚谱系稍后分裂，但不太清楚γδ亚谱系是否已经在第一个TCR控制的检查点或稍后转向。最近的实验支持前一种观点。
αβ and γδ T-cells develop in the thymus from a common precursor. Although lineages initially were defined by the type of TCR they express, it soon became clear that the TCR type per se does not play a deterministic role in the lineage decision, since in various transgenic and knockout models, as well as in a small fraction of cells in wt mice, the TCRγδ can drive the differentiation of αβ lineage cells and the TCRαβ can drive differentiation of γδ lineage cells. Thus until recently it was unclear what determines lineage choice and at which stage the two lineages diverge. Recent observations suggest that TCR signal strength determines lineage fate and that lineage choice is made at or shortly after the first TCR-controlled checkpoint. While it is clear that the decision between αβ and γδ lineages is made at the first TCR controlled checkpoint and the αβ sublineages split off later, it is less clear whether γδ sublineages divert already at the first TCR controlled checkpoint or later. Recent experiments support the former view.
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影响因子：
4.4
作者：
Ciofani, M;Schmitt, TM;Zúñiga-Pflücker, JC
通讯作者：
Zúñiga-Pflücker, JC
影响因子：
32.4
作者：
Ciofani, Maria;Knowles, Gisele C.;Zuniga-Pflucker, Juan Carlos
通讯作者：
Zuniga-Pflucker, Juan Carlos
影响因子：
4.4
作者：
Hendricks, Deborah W.;Fink, Pamela J.
通讯作者：
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影响因子：
32.4
作者：
Bruno, L;Fehling, HJ;vonBoehmer, H
通讯作者：
vonBoehmer, H
影响因子：
15.3
作者：
Garbe, Annette I.;Krueger, Andreas;von Boehmer, Harald
通讯作者：
von Boehmer, Harald