Role of natural product diversity in chemical biology.

Role of natural product diversity in chemical biology.
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DOI:
10.1016/j.cbpa.2011.03.004
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发表时间:
2011-06
影响因子:
7.8
通讯作者:
Hong, Jiyong
Hong, Jiyong
中科院分区:
生物学2区
文献类型:
--
作者:
Hong, Jiyong

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通过自然选择过程,天然产物具有独特和广泛的化学多样性,并已进化为与生物大分子的最佳相互作用。由于其多样性、靶向亲和力和特异性,天然产物已显示出作为生物分子功能调节剂的巨大潜力,是药物发现的重要来源,并为组合文库开发提供了设计原则。
Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.
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