Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.
Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.
复制标题
低碳水化合物、高蛋白质和高 Omega-3 饮食通过抑制糖异生来抑制餐后血糖波动
DOI：
10.3390/ijms19071823
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发表时间：
2018-06-21
影响因子：
5.6
通讯作者：
Kang JX
中科院分区：
文献类型：
--
作者：
Wang B;Smyl C;Chen CY;Li XY;Huang W;Zhang HM;Pai VJ;Kang JX
高血压显著促进代谢性疾病的发展和进展。控制餐后血糖波动对高血糖患者尤为重要，但仍缺乏安全有效的降低血糖水平的方法。在雄性C57 BL/6 J小鼠中测试了具有不同常量营养素比率和ω-3脂肪酸量的五种饮食的降血糖作用。进一步研究了具有有效降糖作用的饮食的潜在机制及其对高血糖模型的有益作用。给予低碳水化合物、高蛋白和高omega-3（LCHP+3）饮食的小鼠显示出血糖水平的快速降低，无论喂养与否，血糖水平都保持在较低水平。这些作用与由于肝丙氨酸转氨酶（ALT）的抑制而导致的氨基酸生成减少有关。此外，LCHP+3干预可有效降低几种疾病的血糖水平，包括1型糖尿病、饮食诱导的高血糖症和饮食诱导的代谢综合征。我们的研究结果表明，LCHP+3饮食是一种有效的降血糖饮食，通过抑制血糖生成来抑制餐后血糖波动，对高血糖代谢疾病的管理可能具有很大的临床实用性。
Hyperglycemia significantly contributes to the development and progression of metabolic diseases. Managing postprandial blood glucose fluctuations is of particular importance for patients with hyperglycemia, but safe and effective means of reducing blood glucose levels are still lacking. Five diets with varying macronutrient ratios and omega-3 fatty acid amounts were tested for their blood glucose-lowering effects in male C57BL/6J mice. The diets with potent blood glucose-lowering effects were further investigated for their underlying mechanisms and their beneficial effects on hyperglycemia models. Mice given the low-carbohydrate, high-protein, and high-omega-3 (LCHP+3) diet exhibited a rapid reduction of the blood glucose levels that remained consistently low, regardless of feeding. These effects were associated with reduced amino acid gluconeogenesis, due to the inhibition of hepatic alanine transaminase (ALT). Furthermore, the LCHP+3 intervention was effective in reducing the blood glucose levels in several disease conditions, including type 1 diabetes mellitus, hormone-induced hyperglycemia, and diet-induced metabolic syndrome. Our findings identify the LCHP+3 diet as a potent blood glucose-lowering diet that suppresses postprandial blood glucose fluctuations through the inhibition of gluconeogenesis and may have great clinical utility for the management of metabolic diseases with hyperglycemia.
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影响因子：
2.1
作者：
Ansari S;Djalali M;Mohammadzadeh Honarvar N;Mazaherioun M;Zarei M;Agh F;Gholampour Z;Javanbakht MH
通讯作者：
Javanbakht MH
影响因子：
5.9
作者：
Jacobo-Cejudo MG;Valdés-Ramos R;Guadarrama-López AL;Pardo-Morales RV;Martínez-Carrillo BE;Harbige LS
通讯作者：
Harbige LS
影响因子：
--
作者：
GOLDEN, S;CHENOWETH, M;KATZ, J
通讯作者：
KATZ, J
影响因子：
3
作者：
Hirsch, IB;Brownlee, M
通讯作者：
Brownlee, M
影响因子：
--
作者：
Kang JX;Wang J
通讯作者：
Wang J