Pharmacokinetic profile of recombinant human (rh) inhibin A and activin A in the immature rat. II. Tissue distribution of [125I]rh-inhibin A and [125I]rh-activin A in immature female and male rats.
Pharmacokinetic profile of recombinant human (rh) inhibin A and activin A in the immature rat. II. Tissue distribution of [125I]rh-inhibin A and [125I]rh-activin A in immature female and male rats.
复制标题
重组人 (rh) 抑制素 A 和激活素 A 在未成熟大鼠中的药代动力学特征。
作者：
T. Woodruff;L. Krummen;S. Chen;R. Lyon;S. E. Hansen;G. DeGuzman;R. Covello;J. Mather;P. Cossum
在未成熟雌性大鼠静脉注射放射性标记蛋白后，测定重组人抑制素A （rh-inhibin A）和rh-activin A的组织分布。[125I]rh-抑制素A和[125I]rh-激活素A在未成熟雌性大鼠组织中的分布不同，通过组织学检查（全身放射自显影和薄切片分析），并通过计算单个组织的剂量百分比和组织血比。[125I]静脉注射后rh-抑制素A在脾脏、肾上腺、骨髓和卵巢中积累。在垂体前叶和后叶也发现了碘化的rh-抑制素A。[125I]静脉注射后在卵巢和垂体中发现rh-激活素A。在脾脏或肾上腺中没有发现特异性结合。骨髓积累了一些[125I]rh-激活素A，与rh-激活素A竞争。放射性的主要排泄途径是肾脏，在静脉注射后10 min出现膀胱标记。rh-抑制素A和rh-激活素A不仅具有不同的药代动力学，而且与rh-抑制素A相比，放射性rh-激活素A的组织积累较少。
The tissue distribution of recombinant human inhibin A (rh-inhibin A) and rh-activin A was determined in immature female Sprague Dawley-derived rats after iv administration of radiolabeled proteins. [125I]rh-Inhibin A and [125I]rh-activin A diverge in their distribution to tissues of the immature female rat as examined histologically (whole body autoradiography and thin section analysis) and by computing the percent dose and tissue to blood ratios for individual tissues. [125I]rh-inhibin A accumulated in the spleen, adrenal, bone marrow, and ovary after iv injection. Iodinated rh-inhibin A was also found in the anterior and posterior pituitary. [125I]rh-activin A was found in the ovary and pituitary after iv injection. Little specific binding was found in the spleen or adrenal. The bone marrow accumulated some [125I]rh-activin A which was competed by rh-activin A. The primary route of excretion for radioactivity was the kidney, with the label appearing in the bladder by 10 min after iv injection. Not only do rh-inhibin A and rh-activin A have different pharmacokinetics, but fewer tissues accumulate radioactive rh-activin A than rh-inhibin A.
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大鼠卵巢抑制素合成的调节。
影响因子：
18.2
作者：
Woodruff,TK;Mayo,KE
通讯作者：
Mayo,KE
人血清和卵泡液中的激活素结合蛋白。
DOI：
10.1210/jcem.74.6.1592877
发表时间：
1992
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Schneyer,AL;O'Neil,DA;CrowleyJr,WF
通讯作者：
CrowleyJr,WF
人重组激活素 A 在体外抑制人胎儿肾上腺细胞的增殖。
DOI：
10.1210/jcem-71-6-1678
发表时间：
1990
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Spencer,SJ;Rabinovici,J;Jaffe,RB
通讯作者：
Jaffe,RB
转化生长因子和抑制素相关蛋白对体外大鼠排卵前卵泡的影响。
影响因子：
4.8
作者：
Tsafriri,A;Vale,W;Hsueh,AJ
通讯作者：
Hsueh,AJ
大鼠卵巢卵泡和黄体中α2-巨球蛋白的激素调节和组织特异性定位。
影响因子：
4.8
作者：
Gaddy-Kurten,D;Hickey,GJ;Fey,GH;Gauldie,J;Richards,JS
通讯作者：
Richards,JS