A prospective analysis of telomere length and pancreatic cancer in the alpha-tocopherol beta-carotene cancer (ATBC) prevention study.
A prospective analysis of telomere length and pancreatic cancer in the alpha-tocopherol beta-carotene cancer (ATBC) prevention study.
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DOI：
10.1002/ijc.28272
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发表时间：
2013-12-01
影响因子：
6.4
通讯作者：
Stolzenberg-Solomon RZ
中科院分区：
文献类型：
--
作者：
Lynch SM;Major JM;Cawthon R;Weinstein SJ;Virtamo J;Lan Q;Rothman N;Albanes D;Stolzenberg-Solomon RZ
吸烟和糖尿病，胰腺癌的一贯危险因素，也是影响端粒长度维持的因素。为了测试端粒长度是否与胰腺癌风险相关，我们在α -生育酚、β -胡萝卜素癌症预防（ATBC）研究队列中进行了一项巢式病例对照研究，研究对象为基线年龄为50-69岁的男性吸烟者。1992年至2004年间，193例胰腺腺癌（平均抽血随访：6.3年）发生在有全血样本用于端粒长度测定的参与者中。对于这些病例和660名对照，我们使用无条件逻辑回归计算优势比（OR）和95%置信区间，调整年龄、经常吸烟的年数和糖尿病史。端粒长度分为四分位数（从最短到最长），并作为分类变量和连续正常变量进行分析（报告端粒长度每增加0.2个单位）。所有统计检验均为双侧检验。端粒长度较长与胰腺癌风险增加显著相关（连续OR=1.26 95% CI= 1.09-1.46；最高四分位数与最低四分位数相比，OR=1.57, 95% CI= 1.01-2.43, p-trend=0.007）。在抽血后5年内确诊的受试者中，这种关联仍然存在（连续OR=1.46, 95%CI= 1.19-1.79，最高四分位数OR=2.92, 95%CI= 1.47-5.77, p-trend=0.002），但在抽血后5年内确诊的受试者中不存在（连续OR=1.03, 95%CI= 0.85-1.22；最高四分位数OR=1.04, 95%CI= 0.60-1.79）。这是第一项前瞻性研究，表明较长的血液白细胞端粒长度与胰腺癌风险增加之间存在关联。
Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50–69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow-up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two-sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR=1.26 95% CI=1.09–1.46; highest quartile compared to lowest, OR=1.57, 95% CI=1.01–2.43, p-trend=0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR=1.46, 95% CI=1.19–1.79 highest quartile OR=2.92, 95%CI=1.47–5.77, p-trend=0.002), but not those diagnosed greater than five years after blood draw (continuous OR=1.03, 95%CI=0.85–1.22; highest quartile OR=1.04, 95%CI=0.60–1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk.
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影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5
作者：
Fitzpatrick, Annette L.;Kronmal, Richard A.;Aviv, Abraham
通讯作者：
Aviv, Abraham
DOI：
10.1158/1055-9965.epi-08-0880
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Genkinger JM;Spiegelman D;Anderson KE;Bergkvist L;Bernstein L;van den Brandt PA;English DR;Freudenheim JL;Fuchs CS;Giles GG;Giovannucci E;Hankinson SE;Horn-Ross PL;Leitzmann M;Männistö S;Marshall JR;McCullough ML;Miller AB;Reding DJ;Robien K;Rohan TE;Schatzkin A;Stevens VL;Stolzenberg-Solomon RZ;Verhage BA;Wolk A;Ziegler RG;Smith-Warner SA
通讯作者：
Smith-Warner SA
影响因子：
3.2
作者：
Hashimoto, Yasushi;Murakami, Yoshiaki;Hiyama, Eiso
通讯作者：
Hiyama, Eiso