Transcriptomics: a Solution for Renal Osteodystrophy?
Transcriptomics: a Solution for Renal Osteodystrophy?
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DOI：
10.1007/s11914-020-00583-6
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发表时间：
2020-06
影响因子：
4.3
通讯作者：
David V
中科院分区：
文献类型：
--
作者：
Martin A;David V
The molecular mechanisms of the bone disease associated with chronic kidney disease (CKD), called renal osteodystrophy (ROD), are poorly understood. New transcriptomics technologies may provide clinically relevant insights into the pathogenesis of ROD. This review summarizes current progress and limitations in the study and treatment of ROD, and in transcriptomics analyses of skeletal tissues. ROD is characterized by poor bone quality and strength leading to increased risk of fracture. Recent studies indicate permanent alterations in bone cell populations during ROD. Single cell transcriptomics analyzes, successful at identifying specialized cell sub populations in bone, have not yet been performed in ROD. ROD is a widespread poorly understood bone disease with limited treatment options. Transcriptomics analyses of bone are needed to identify the bone cell subtypes and their role in the pathogenesis of ROD, and to develop adequate diagnosis and treatment strategies.
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