Why can't we find a new treatment for SLE?
Why can't we find a new treatment for SLE?
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DOI：
10.1016/j.jaut.2009.02.006
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发表时间：
2009-05
影响因子：
12.8
通讯作者：
Eisenberg R
中科院分区：
文献类型：
--
作者：
Eisenberg R
没有新的治疗系统性红斑狼疮已被批准。在过去的十年中，已经开发了几种新的化合物用于狼疮，但到目前为止还没有被证明是有效的。这篇综述讨论了一些原因，为什么它可能是如此困难，以证明一种新的治疗方法是有效的这种疾病。这些因素包括疾病本身的复杂性;缺乏可靠的结局指标;我们对疾病发病机制的了解有限;狼疮患者倾向于出现不良结局并以不寻常的方式对药物作出反应;患者人群的异质性;个体患者的疾病进程不可预测;以及缺乏可靠的生物标志物。尽管一些显然基于强有力的临床前和机理数据的测试的靶向化合物可能确实不是SLE的有效疗法，但很难不相信，在目前正在测试的各种特异性药物中，它们中的至少一些应该下调SLE的异常免疫调节特征，从而在临床上有效。我们需要坚持不懈和富有想象力地确定这些有效的药物，并证明它们的功效，以便它们可以广泛用于我们的狼疮人群。
No new therapy for systemic lupus erythematosus has been approved. In the last decade, the development of several novel compounds has been pursued for lupus, but so far nothing has been proven to be effective. This review discusses some of the reasons why it may be so difficulty to demonstrate that a novel therapy is effective for this disease. These include the complexity of the disease itself; the lack of reliable outcome measures; our limited understanding of the pathogenesis of the disease; the propensity of lupus patients to have bad outcomes and to react to medicines in unusual ways; the heterogeneity of the patient population; the unpredictable course of disease in individual patients; and the lack of reliable biomarkers. Although some of the tested targeted compounds that are apparently based on strong preclinical and mechanistic data may indeed not be effective therapies for SLE, it is hard not to believe that among the various specific agents now being tested that at least some of them should downregulate the abnormal immunoregulation characteristic of SLE, and thus be clinically effective. We need to be persistent and imaginative in identifying these effective agents and proving their efficacy so that they may be widely used in our lupus populations.
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影响因子：
2.6
作者：
Bijl, Marc;Kallenberg, Cees G. M.
通讯作者：
Kallenberg, Cees G. M.
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Lai, KN
DOI：
10.2215/cjn.00170108
发表时间：
2008-05-01
影响因子：
9.8
作者：
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通讯作者：
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影响因子：
15.9
作者：
EISENBERG, RA;CRAVEN, SY;COHEN, PL
通讯作者：
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