Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.
Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.
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DOI：
10.1093/ecam/neh020
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发表时间：
2004-09-01
期刊：
影响因子：
--
通讯作者：
Kanda T
中科院分区：
文献类型：
--
作者：
Wang XQ;Takahashi T;Zhu SJ;Moriya J;Saegusa S;Yamakawa J;Kusaka K;Itoh T;Kanda T
我们旨在评估日本草药hohu -ekki-to （TJ-41）对慢性疲劳综合征（CFS）小鼠模型日常活动的影响。每2周反复注射流产布鲁氏菌（Brucella abortus， BA）抗原诱导CFS。TJ-41以500 mg/kg/天的剂量口服小鼠，注射BA前1周，注射BA后4周。我们评估了接受TJ-41治疗的小鼠与未接受TJ-41治疗的小鼠的日常跑步活动。观察期间监测两组小鼠的生存情况。测定两组大鼠牺牲时体重（BW）、脾重（SW）、脾重比（SW / BW）及脾脏白细胞介素-10 (IL-10) mRNA表达水平。治疗组的日活动量明显高于对照组。未给药组2只小鼠在第二次注射BA后2 d死亡，而TJ-41给药组无小鼠死亡。与对照组相比，治疗组小鼠的SW和SW/BW显著降低。经TJ-41处理后，小鼠脾脏IL-10 mRNA水平受到抑制。我们的数据表明，虎竹益基对BA注射后明显降低的跑步活性可能具有抑制作用。
We aimed to evaluate the effect of a Japanese herbal medicine, Hochu-ekki-to (TJ-41), on daily activity in a murine model of chronic fatigue syndrome (CFS). CFS was induced by repeated injection of Brucella abortus (BA) antigen every 2 weeks. TJ-41 was orally administered to mice in a dose of 500 mg/kg/day for 1 week before injecting BA and for 4 weeks thereafter. We evaluated daily running activity in mice receiving TJ-41 as compared with that in untreated mice. Survival of both mouse groups was also monitored during the observation period. Body weight (BW), spleen weight (SW), SW/ BW ratio and expression levels of interleukin-10 (IL-10) mRNA in spleen were determined in both groups at the time of sacrifice. The daily activity was significantly higher in the treated group than in the control. Two mice in the untreated group died 2 days after the second injection of BA, whereas no mice in the group treated with TJ-41 died. The SW and SW/BW ratio were significantly lower in the treated mice than in the control. Suppressed IL-10 mRNA levels were observed in the spleens of the mice treated with TJ-41. Our data suggest that Hochu-ekki-to might possess an inhibitory effect on the marked decrease in running activity following BA injection.
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