Ankylosing spondylitis and rheumatoid arthritis: serum levels of TNF-α and Its soluble receptors during the course of therapy with etanercept and infliximab.
Ankylosing spondylitis and rheumatoid arthritis: serum levels of TNF-α and Its soluble receptors during the course of therapy with etanercept and infliximab.
复制标题
DOI：
10.1155/2014/675108
复制
发表时间：
2014
影响因子：
--
通讯作者：
Neeck G
中科院分区：
文献类型：
--
作者：
Schulz M;Dotzlaw H;Neeck G
在接受任一化合物治疗的强直性脊柱炎（AS）和类风湿性关节炎（RA）患者中，测定了TNF-α阻滞剂英夫利西单抗或依那西普对TNF-α、TNF-受体1（TNF-R1）和TNF-受体2（TNF-R2）水平以及炎症标志物CRP和IL-6水平的影响。发现RA患者治疗前TNF-α水平较健康人和AS患者有升高趋势（P < 0.05）。在治疗过程中，我们在AS和RA依那西普患者组中测得TNF-α水平显著升高，而在英夫利西单抗治疗的患者中，测得的TNF-α水平保持不变。在我们的研究组中，依那西普治疗患者中TNF-α升高似乎不是自发发生进一步自身免疫性疾病的显著风险因素。与健康对照组相比，AS（P < 0.05）和RA（P < 0.001）患者的TNF-R1水平均升高。在AS患者中，TNF-R1水平在英夫利西单抗（P < 0.01）或依那西普（P < 0.001）治疗后显著下降。相比之下，这种受体的水平保持不变，在RA患者与任一化合物治疗。
The effects of the TNF-α blockers infliximab or etanercept on the levels of TNF-α, TNF-receptor 1 (TNF-R1), and TNF-receptor 2 (TNF-R2), as well as the levels of the inflammation markers CRP and IL-6, were measured in ankylosing spondylitis (AS) and rheumatoid arthritis (RA) patients receiving treatment with either compound. We found that RA patients tend to have higher levels of TNF-α than both healthy individuals and AS patients prior to treatment (P < 0.05). We measured greatly increased levels of TNF-α in both the AS and RA etanercept patient groups during the course of treatment, while in the infliximab treated patients, the amount of TNF-α measured remained unchanged. Elevated TNF-α in the etanercept treated patients does not appear to be a significant risk factor for the spontaneous development of further autoimmune diseases in our study group. Increased levels of TNF-R1 were determined in both AS (P < 0.05) and RA (P < 0.001) patients when compared to healthy controls. In AS patients, the levels of TNF-R1 dropped significantly when treated with either infliximab (P < 0.01) or etanercept (P < 0.001). In contrast, the levels of this receptor remained unchanged in RA patients treated with either compound.
登录
查看更多内容
影响因子：
2.4
作者：
Coelho, Fernanda Matos;Reis, Helton Jose;Teixeira, Antonio Lucio
通讯作者：
Teixeira, Antonio Lucio
DOI：
10.1084/jem.20040435
发表时间：
2004-08-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Xanthoulea S;Pasparakis M;Kousteni S;Brakebusch C;Wallach D;Bauer J;Lassmann H;Kollias G
通讯作者：
Kollias G
影响因子：
--
作者：
DOUGADOS, M;VANDERLINDEN, S;ZEIDLER, H
通讯作者：
ZEIDLER, H
影响因子：
27.4
作者：
Zou, J;Rudwaleit, M;Sieper, J
通讯作者：
Sieper, J
影响因子：
5.5
作者：
Nowlan, ML;Drewe, E;Todd, I
通讯作者：
Todd, I