Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer.
Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer.
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DOI：
10.1007/s13402-016-0297-1
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Babashah S
中科院分区：
文献类型：
--
作者：
Chavez-Gonzalez A;Bakhshinejad B;Pakravan K;Guzman ML;Babashah S
肿瘤干细胞（cancer stem cells，CSCs）又称肿瘤起始细胞（tumor-initiating cells，TIC），具有高度的自我更新和多向分化能力。CSC被认为在许多类型的癌症的发生、发展和转移中起着不可或缺的作用。白血病被认为是由CSC的特定亚型，白血病干细胞（LSC）引发和维持的。LSC的一个重要特征是它们对标准疗法的抗性，这可能导致复发。越来越多的努力旨在开发新的治疗策略，选择性地靶向LSC，同时保留其正常对应物，从而最大限度地减少不良治疗相关的副作用。这些LSC靶向疗法旨在通过影响控制其存活、自我更新、分化、增殖和细胞周期进程的机制来根除LSC。一些LSC靶向疗法已经在临床前研究中被证明是成功的，它们现在正在临床研究中进行测试，主要是与常规治疗方案相结合。越来越多的证据表明，选择性靶向LSC是改善疾病结局的一种有前途的方法。毫无疑问，CSC假说为抗癌研究领域增加了一个新的维度，从而为塑造癌症治疗的新趋势铺平了道路。
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are characterized by high self-renewal and multi-lineage differentiation capacities. CSCs are thought to play indispensable roles in the initiation, progression and metastasis of many types of cancer. Leukemias are thought to be initiated and maintained by a specific sub-type of CSC, the leukemia stem cell (LSC). An important feature of LSCs is their resistance to standard therapy, which may lead to relapse. Increasing efforts are aimed at developing novel therapeutic strategies that selectively target LSCs, while sparing their normal counterparts and, thus, minimizing adverse treatment-associated side-effects. These LSC targeting therapies aim to eradicate LSCs through affecting mechanisms that control their survival, self-renewal, differentiation, proliferation and cell cycle progression. Some LSC targeting therapies have already been proven successful in pre-clinical studies and they are now being tested in clinical studies, mainly in combination with conventional treatment regimens. A growing body of evidence indicates that the selective targeting of LSCs represents a promising approach to improve disease outcome. Beyond doubt, the CSC hypothesis has added a new dimension to the area of anticancer research, thereby paving the way for shaping a new trend in cancer therapy.
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DOI：
10.1084/jem.20100523
发表时间：
2010-04-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
11.4
作者：
Black, JH;McCubrey, JA;Frankel, AE
通讯作者：
Frankel, AE
影响因子：
8
作者：
Billottet, C.;Grandage, V. L.;Khwaja, A.
通讯作者：
Khwaja, A.
影响因子：
11.4
作者：
Brault, L.;Rovo, A.;Schwaller, J.
通讯作者：
Schwaller, J.
影响因子：
4.2
作者：
Cierpicki T;Grembecka J
通讯作者：
Grembecka J