EGFR mutational status in a large series of Caucasian European NSCLC patients: data from daily practice.
EGFR mutational status in a large series of Caucasian European NSCLC patients: data from daily practice.
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DOI：
10.1038/bjc.2013.511
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发表时间：
2013-10-01
影响因子：
8.8
通讯作者：
Dietmaier, W.
中科院分区：
文献类型：
--
作者：
Gahr, S.;Stoehr, R.;Geissinger, E.;Ficker, J. H.;Brueckl, W. M.;Gschwendtner, A.;Gattenloehner, S.;Fuchs, F. S.;Schulz, C.;Rieker, R. J.;Hartmann, A.;Ruemmele, P.;Dietmaier, W.
转移性非小细胞肺癌（NSCLC）的预后仍然很差。激活上皮生长因子受体（EGFR）突变是具有显著治疗意义的重要遗传改变。到目前为止，与亚洲人群相比，高加索人，尤其是欧洲种族患者中这些突变的患病率数据有限。在这项多中心研究中，对来自德国南部的1201例NSCLC患者进行了EGFR突变状态的日常临床常规检测。在所有肿瘤中发现了9.8%的激活EGFR突变。外显子18、19和21的突变分别占全部突变的4.2%、61.9%和33.1%。非吸烟者EGFR突变率显著高于吸烟者和既往吸烟者（24.4%vs4.2%P <0.001）。非鳞片状非粘液腺癌（G2）占所有激活EGFR突变的45.5%，所有鳞状细胞癌的3.5%检测为阳性。甲状腺转录因子1蛋白表达与EGFR突变状态显著相关。这些来自德国临床常规的综合数据增加了对与NSCLC EGFR突变状态相关的临床和组织病理学因素的了解。
The prognosis of metastatic non-small cell lung cancer (NSCLC) is still poor. Activating epithelial growth factor receptor (EGFR) mutations are important genetic alterations with dramatic therapeutical implications. Up to now, in contrast to Asian populations only limited data on the prevalence of those mutations are available from patients with Caucasian and especially European ethnicity. In this multicentre study, 1201 unselected NSCLC patients from Southern Germany were tested in the daily clinical routine for EGFR mutation status. Activating EGFR mutations were found in 9.8% of all tumours. Mutations in exons 18, 19 and 21 accounted for 4.2%, 61.9% and 33.1% of all mutations, respectively. Non-smokers had a significantly higher rate of EGFR mutations than smokers or ex-smokers (24.4% vs 4.2% P<0.001). Non-lepidic-non-mucinous adenocarcinomas (G2) accounted for 45.5% of all activating EGFR mutations and 3.5% of all squamous cell carcinomas were tested positive. Thyroid transcription factor 1 protein expression was significantly associated with EGFR mutational status. These comprehensive data from clinical routine in Germany add to the knowledge of clinical and histopathological factors associated with EGFR mutational status in NSCLC.
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影响因子：
158.5
作者：
Lynch, TJ;Bell, DW;Haber, DA
通讯作者：
Haber, DA
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
表皮生长因子受体和KRAS突变对以前未经治疗的非小细胞肺癌患者的临床结果的影响：临床试验的在线肿瘤注册表的结果。
DOI：
10.1158/1078-0432.ccr-09-0888
发表时间：
2009-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jackman DM;Miller VA;Cioffredi LA;Yeap BY;Jänne PA;Riely GJ;Ruiz MG;Giaccone G;Sequist LV;Johnson BE
通讯作者：
Johnson BE
影响因子：
20.4
作者：
Ludovini, Vienna;Bianconi, Fortunato;Crino, Lucio
通讯作者：
Crino, Lucio
影响因子：
8
作者：
Gazdar, A. F.
通讯作者：
Gazdar, A. F.