Is Mucormycosis an inevitable complication of Covid-19 in India?
Is Mucormycosis an inevitable complication of Covid-19 in India?
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DOI：
10.1016/j.bjid.2021.101597
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Manohar S
中科院分区：
文献类型：
--
作者：
Bhogireddy R;Krishnamurthy V;Jabaris S SL;Pullaiah CP;Manohar S
毛霉菌病或黑真菌感染是一种不太常见的疾病，但高度致命的感染，感染免疫功能低下的个人。该真菌的好发部位被发现是肺和脑，除了它的隔离在窦空间。目前，随着COVID 19大流行的持续，这种感染在印度人口中的患病率很高。真菌通过影响个体受损的免疫系统来建立自身，从而使个体易受其他疾病/感染。类固醇治疗药物滥用、托珠单抗治疗和糖尿病是导致疫情突然激增的原因。为了避免细胞因子风暴，医疗卫生工作者有必要将类固醇药物纳入COVID 19治疗方案中，但将这些药物纳入确实需要类固醇的患者可能会削弱他们的免疫系统，并允许这种真菌入侵。根据国际糖尿病联合会（IDF）的数据，已知有7700万印度人患有糖尿病，警告医生在这些人患COVID 19的情况下警惕即将发生的黑真菌感染。抗高血糖药物与免疫系统减弱和真菌入侵机会之间存在因果关系。这篇综述试图解释COVID 19感染的相互关系，其治疗和最终的黑真菌感染风险。
Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. The fungus establishes itself by affecting the compromised immune system of an individual and thereby making the individual susceptible to other diseases/infection. The reasons attributed to the sudden upsurge are steroidal therapeutics abuse, tocilizumab therapy and diabetes mellitus.To avert the cytokine storm, the medical health workers are necessitated to include steroid drugs in COVID 19 treatment protocol however inclusion of these drugs in patients who do essentially require steroids can have their immune system debilitated and permit the invasion of this fungus. According to International Diabetes Federation (IDF), 77 million Indians are known to be diabetic, cautioning the physicians to be vigilante of the impending black fungus infection in the event of COVID19 affliction in such individuals. There is causal relationship between anti-hyperglycemic drugs and weakened immune system and opportunity for the fungus invasion. This review attempts to explain the inter-relatedness of COVID19 infection, its treatment and eventual black fungus infection risk.
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DOI：
10.1016/j.dsx.2021.05.019
发表时间：
2021-07
期刊：
Diabetes & metabolic syndrome
影响因子：
--
作者：
Singh AK;Singh R;Joshi SR;Misra A
通讯作者：
Misra A
影响因子：
15.9
作者：
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通讯作者：
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DOI：
10.3390/diseases4030026
发表时间：
2016-07-25
期刊：
Diseases (Basel, Switzerland)
影响因子：
--
作者：
Lim YX;Ng YL;Tam JP;Liu DX
通讯作者：
Liu DX
影响因子：
11.8
作者：
Ibrahim, Ashraf S.;Spellberg, Brad;Kontoyiannis, Dimitrios P.
通讯作者：
Kontoyiannis, Dimitrios P.
影响因子：
12.7
作者：
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通讯作者：
Jahandideh, Arash