Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?
Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?
复制标题
DOI：
10.1586/eci.10.83
复制
发表时间：
2011-01
影响因子：
4.4
通讯作者：
Keshavarzian A
中科院分区：
文献类型：
--
作者：
Swanson GR;Burgess HJ;Keshavarzian A
Inflammatory bowel disease (IBD) is a waxing and waning disease characterized by diarrhea, abdominal pain and weight loss. Recently, there has been an increased interest in the roles that sleep, circadian rhythms and melatonin could have as regulators of inflammation in the Gl tract. Advances in our understanding of the molecular machinery of the circadian clock, and the discovery of clock genes in the GI tract are opening up new avenues of research for a role of sleep in IBD. Altering circadian rhythm significantly worsens the development of colitis in animal models, and preliminary human studies have shown that patients with IBD are at increased risk for altered sleep patterns. Further research is needed to clarify the role of disturbances in IBD.
登录
查看更多内容
影响因子：
8.2
作者：
Hoogerwerf, Willemijntje A.
通讯作者：
Hoogerwerf, Willemijntje A.
影响因子：
2.2
作者：
Chandrasekhara, Pradeep Kumar Shenoy;Jayachandran, Nambiar Veettil;Narsimulu, Gumdal
通讯作者：
Narsimulu, Gumdal
影响因子：
29.4
作者：
Hoogerwerf, Willemijntje A.;Hellmich, Helen L.;Cassone, Vincent M.
通讯作者：
Cassone, Vincent M.
影响因子：
3.1
作者：
FARMER, RG;EASLEY, KA;RANKIN, GB
通讯作者：
RANKIN, GB
影响因子：
4.6
作者：
Li JH;Yu JP;Yu HG;Xu XM;Yu LL;Liu J;Luo HS
通讯作者：
Luo HS