Morphing methods to parameterize specimen-specific finite element model geometries.
Morphing methods to parameterize specimen-specific finite element model geometries.
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DOI：
10.1016/j.jbiomech.2009.08.036
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发表时间：
2010-01-19
影响因子：
2.4
通讯作者：
Downs, J. Crawford
中科院分区：
文献类型：
--
作者：
Sigal, Ian A.;Yang, Hongli;Roberts, Michael D.;Downs, J. Crawford
关键词：
形状在决定一个结构的生物力学响应方面起着重要作用。特定标本的有限元（FE）模型已被开发出来，以捕捉生物结构形状的细节并预测其生物力学特性。然而，形状在个体之间可能有很大差异，或者由于衰老或疾病而发生改变，对特定标本模型针对这些变化的敏感性分析已被证明具有挑战性。特定标本表示法的一种替代方法是开发具有简化几何形状的通用模型，其形状相对容易参数化，因此可轻易用于敏感性研究。尽管有许多成功的应用，但通用模型的局限性在于它们无法对单个标本进行预测。
我们提出，有可能在利用通用模型中常见的参数化技术的优势的同时，利用特定标本模型中可用的细节。在这项工作中，我们表明这可以通过使用变形技术对特定标本的有限元模型的几何形状进行参数化来实现，这样模型形状就可以以一种适合敏感性分析的可控且系统的方式改变。我们通过在眼睛后极承重组织的模型上使用三种变形技术来进行演示。我们表明，使用相对简单的程序，这些变形技术可以组合，这允许对因素相互作用进行研究。最后，我们通过将这些技术应用于股骨变形来说明它们可用于其他系统。变形技术为分析形状的生物力学作用（独立地或与载荷和材料特性相互作用）提供了一种令人兴奋的新可能性。
Shape plays an important role in determining the biomechanical response of a structure. Specimen-specific finite element (FE) models have been developed to capture the details of the shape of biological structures and predict their biomechanics. Shape, however, can vary considerably across individuals or change due to aging or disease, and analysis of the sensitivity of specimen-specific models to these variations has proven challenging. An alternative to specimen-specific representation has been to develop generic models with simplified geometries whose shape is relatively easy to parameterize, and can therefore be readily used in sensitivity studies. Despite many successful applications, generic models are limited in that they cannot make predictions for individual specimens. We propose that it is possible to harness the detail available in specimen-specific models while leveraging the power of the parameterization techniques common in generic models. In this work we show that this can be accomplished by using morphing techniques to parameterize the geometry of specimen-specific FE models such that the model shape can be varied in a controlled and systematic way suitable for sensitivity analysis. We demonstrate three morphing techniques by using them on a model of the load-bearing tissues of the posterior pole of the eye. We show that using relatively straightforward procedures these morphing techniques can be combined, which allows the study of factor interactions. Finally, we illustrate that the techniques can be used in other systems by applying them to morph a femur. Morphing techniques provide an exciting new possibility for the analysis of the biomechanical role of shape, independently or interaction with loading and material properties.
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