A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells.
A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells.
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DOI：
10.1111/j.1349-7006.1999.tb00690.x
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发表时间：
1999-10
期刊：
影响因子：
--
通讯作者：
Tsukuda M
中科院分区：
文献类型：
--
作者：
Nishimura G;Yanoma S;Mizuno H;Kawakami K;Tsukuda M
使用人头颈部鳞状细胞癌细胞系KB检查了选择性环氧合酶（考克斯）-2抑制剂JTE-522的抗肿瘤作用。KB细胞不产生前列腺素（PG）-E2。在体外，JTE-522诱导G1期阻滞细胞增加，抑制血小板衍生生长因子（PDGF）的产生和抑制端粒酶活性。未检测到细胞毒性效应。在体内，JTE-522显著抑制了裸鼠异种移植瘤的生长。观察到肿瘤周围血管生成抑制、G1期阻滞细胞增加和端粒酶活性抑制，以及肿瘤中凋亡细胞死亡增加。免疫增强没有发挥作用。我们得出结论，JTE-522的抗肿瘤作用是由抗血管生成作用、细胞周期阻滞和抑制肿瘤细胞的端粒酶活性引起的。这些联合作用可能诱导细胞凋亡。
The anti‐tumor effect of a selective cyclooxygenase (COX)‐2 inhibitor, JTE‐522, was examined with the human head and neck squamous cell carcinoma cell line KB. KB cells do not produce prostaglandin (PG)‐E2. In vitro, JTE‐522 induced an increase of G1 phase‐arrested cells, suppression of platelet‐derived growth factor (PDGF) production and inhibition of telomerase activity. No cytotoxic effect was detected. In vivo, the growth of the tumor xenografted into nude mice was significantly suppressed by JTE‐522. Suppression of angiogenesis at the periphery of the tumor, increase of G1‐arrested cells and suppression of telomerase activity were observed, together with an increase of apoptotic cell death in the tumor. Immunological enhancement did not play a role. We concluded that the anti‐tumor effect of JTE‐522 was caused by anti‐angiogenesis action, cell cycle arrest and inhibition of telomerase activity of the tumor cells. These combined effects might induce apoptosis.
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DOI：
10.1111/j.1349-7006.1998.tb00499.x
发表时间：
1998-10-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
Kido, A;Tsujiuchi, T;Konishi, Y
通讯作者：
Konishi, Y
影响因子：
3.9
作者：
METZGER, U;MEIER, J;WEIHE, H
通讯作者：
WEIHE, H
影响因子：
29.4
作者：
DuBois, RN;Radhika, A;Entingh, AJ
通讯作者：
Entingh, AJ
影响因子：
4.7
作者：
Denda, A;Endoh, T;Konishi, Y
通讯作者：
Konishi, Y
影响因子：
9.6
作者：
NUGENT, KP;FARMER, KCR;PHILLIPS, RKS
通讯作者：
PHILLIPS, RKS