Arsenic exposure and age and sex-specific risk for skin lesions: a population-based case-referent study in Bangladesh.
Arsenic exposure and age and sex-specific risk for skin lesions: a population-based case-referent study in Bangladesh.
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DOI：
10.1289/ehp.9207
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发表时间：
2006-12
影响因子：
10.4
通讯作者：
Persson LA
中科院分区：
文献类型：
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作者：
Rahman M;Vahter M;Sohel N;Yunus M;Wahed MA;Streatfield PK;Ekström EC;Persson LA
在孟加拉国的Matlab进行的这项以人群为基础的病例参考研究的目的是评估饮用砷污染管井威尔斯水的人群中，按年龄和性别对砷诱导的皮肤病变的易感性。砷相关皮肤病变的识别分三步进行：a）由经过培训的现场小组对所有> 4岁的人群（n = 166，934）进行筛查; B）由医生诊断疑似砷相关病例; c）由专家根据医生的记录和照片进行确认。共有504例皮肤病变得到证实。我们从Matlab健康和人口统计学监测系统中随机选择了2，201名参考对象; 1，955名合格，1，830名（94%）可参与研究。个体砷暴露史是基于访谈中获得的信息，包括自1970年以来使用的所有饮用水源和使用的所有管威尔斯中的砷浓度（通过原子吸收分光光度法评估）。1970年以来的平均暴露量：男性200 μg/L，女性211 μg/L，男性143 μg/L，女性155 μg/L。我们发现了一个剂量-反应关系的男女（p < 0.001），并增加风险与社会经济地位的增加。在最高平均暴露五分位数（p = 0.005）中，男性发生皮肤病变的风险高于女性（比值比10.9 vs. 5.78）。与在生命后期开始接触砷相比，在1岁之前开始接触砷（累积接触）与获得皮肤病变的风险较高无关。结果表明，男性比女性更容易发展皮肤病变时，暴露于水中的砷从管威尔斯。
The objective of this population-based case–referent study in Matlab, Bangladesh, was to assess the susceptibility to arsenic-induced skin lesions by age and sex, in a population drinking water from As-contaminated tube wells. Identification of As-related skin lesions was carried out in three steps: a) screening of the entire population > 4 years of age (n = 166,934) by trained field teams; b) diagnosis of suspected As-related cases by physicians; and c) confirmation by experts based on physicians’ records and photographs. A total of 504 cases with skin lesions were confirmed. We randomly selected 2,201 referents from the Matlab health and demographic surveillance system; 1,955 were eligible, and 1,830 (94%) were available for participation in the study. Individual history of As exposure was based on information obtained during interviews and included all drinking-water sources used since 1970 and concentrations of As (assessed by atomic absorption spectrophotometry) in all the tube wells used. Cases had been exposed to As more than referents (average exposure since 1970: male cases, 200 μg/L; female cases, 211 μg/L; male referents, 143 μg/L; female referents, 155 μg/L). We found a dose–response relationship for both sexes (p < 0.001) and increased risk with increasing socioeconomic status. Males had a higher risk of obtaining skin lesions than females (odds ratio 10.9 vs. 5.78) in the highest average exposure quintile (p = 0.005). Start of As exposure (cumulative exposure) before 1 year of age was not associated with higher risk of obtaining skin lesions compared to start of As exposure later in life. The results demonstrate that males are more susceptible than females to develop skin lesions when exposed to As in water from tube wells.
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影响因子：
3.6
作者：
Kadono, T;Inaoka, T;Ohtsuka, R
通讯作者：
Ohtsuka, R
影响因子：
7.7
作者：
Mazumder, DNG;Haque, R;Smith, AH
通讯作者：
Smith, AH
影响因子：
10.4
作者：
Concha, G;Nermell, B;Vahter, M
通讯作者：
Vahter, M
影响因子：
4.7
作者：
Moore, LE;Smith, AH;Waldman, FM
通讯作者：
Waldman, FM
影响因子：
8.8
作者：
通讯作者：
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