Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma.
Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma.
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DOI：
10.1038/bjc.2011.368
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发表时间：
2011-10-11
影响因子：
8.8
通讯作者：
Nakajima, Y.
中科院分区：
文献类型：
--
作者：
Hotta, K.;Sho, M.;Fujimoto, K.;Shimada, K.;Yamato, I.;Anai, S.;Konishi, N.;Hirao, Y.;Nonomura, K.;Nakajima, Y.
众所周知，记忆T细胞在人类的宿主防御中起着关键作用。然而，它们在实际人类癌症中的作用在很大程度上仍不清楚。在本研究中，我们试图揭示肿瘤浸润性CD45RO+记忆T细胞在肾癌中的临床意义。我们分析了105例接受根治性或部分肾切除术的肾癌患者。TNM分期I期65例，II期7例，III期15例，IV期18例。免疫组织化学方法检测CD45RO的表达。以同样的方式系统地评估了CD4和CD8的表达。TNM分期越高或核级别越高，CD45RO密度越高。CD45RO状态与术前C反应蛋白水平呈正相关。在预后分析中，CD45RO+LO患者的预后明显好于CD45RO+HI患者。CD_4+LO组和CD_4+H_1组之间也有显著差异，而CD8 T细胞状态无显著差异。多因素分析显示CD45RO+状态是影响患者总生存期的独立预后因素。CD45RO+记忆性T细胞状态具有显著的独立预后价值，表明获得性免疫反应在人肾癌中起着重要的功能作用。
Memory T cells are well known to have a critical role for host defense in humans. However, their role in actual human cancer remains largely unknown. In this study, we tried to reveal the clinical importance of tumour-infiltrating CD45RO+ memory T cells in renal cell carcinoma (RCC). We analysed 105 patients with RCC, who received radical or partial nephrectomy. Those were 65 in TNM stage I, 7 in stage II, 15 in stage III, and 18 in stage IV, respectively. CD45RO expression was evaluated by immunohistochemistry. CD4 and CD8 expressions were also systematically assessed in the same manner. Patients with higher TNM stage or high nuclear grade were found to have higher densities of CD45RO. Furthermore, CD45RO status was positively correlated with preoperative C-reactive protein level. In prognostic analysis, CD45RO+lo patients had a significantly better prognosis than CD45RO+hi patients. There was also a significant difference between CD4+lo and CD4+hi groups, whereas no significant difference was observed in CD8 T-cell status. Finally, multivariate analysis revealed that CD45RO+ status was the independent prognostic factor for patient overall survival. CD45RO+ memory T-cell status has a significant independent prognostic value, indicating that the adaptive immune response is functionally critical in human RCC.
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影响因子：
6.6
作者：
Casamassima, A;Picciariello, M;Guida, M
通讯作者：
Guida, M
影响因子：
45.3
作者：
Motzer, RJ;Mazumdar, M;Ferrara, J
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作者：
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通讯作者：
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