Ethanol/cocaine interaction: cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects.
Ethanol/cocaine interaction: cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects.
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乙醇/可卡因相互作用：可卡因和可卡乙烯血浆浓度及其与主观和心血管效应的关系。
DOI：
10.1016/0024-3205(92)90224-d
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发表时间：
1992
期刊：
影响因子：
6.1
通讯作者：
Jeffcoat,AR
中科院分区：
文献类型：
--
作者：
Perez-Reyes,M;Jeffcoat,AR
为了研究乙醇和可卡因相互作用的药理学效应，11名男性志愿者接受了剂量反应、安慰剂对照、单盲、随机分配的交叉设计试验，他们都熟悉乙醇和可卡因的使用。乙醇（0.85 g/kg）或安慰剂在30分钟内分次服用。终止乙醇摄入15分钟后，通过鼻灌（鼻吸）给予盐酸可卡因（1.25和1.9 mk/kg）或安慰剂（利多卡因和甘露醇）。测量了可卡因和可卡因的血浆浓度、血液乙醇水平、药物作用的主观评分和心血管参数。统计分析结果表明：1)给药不改变血中乙醇浓度，不改变乙醇中毒等级；2)乙醇导致可卡因血浆浓度、可卡因“高”等级和心率显著增加；3)观察对可卡因主观效应和心率效应的急性耐受性；4)当与可卡因混合时，乙醇导致可卡因的缓慢形成，其数量远低于其母体化合物；5)血浆中可卡因的出现并未改变可卡因的主观效应和心血管效应。
To investigate the pharmacologic effects of the interaction between ethanol and cocaine, eleven male, paid volunteers familiar with the use of both ethanol and cocaine were tested in a dose-response, placebo-controlled, single-blind, randomly-assigned, cross-over design. Ethanol (0.85 g/kg) or placebo was administered in divided doses over a thirty minute period. Fifteen minutes after the termination of ethanol ingestion, cocaine HCl (1.25 and 1.9 mk/kg) or placebo (lidocaine and mannitol) was given by nasal insufflation (snorting). Cocaine and cocaethylene plasma concentrations, blood ethanol levels, subjective ratings of drug effects, and cardiovascular parameters were measured. Statistical analysis of the results indicate that: 1) cocaine administration did not alter blood ethanol concentrations nor the ratings of ethanol intoxication; 2) ethanol caused a significant increase in cocaine plasma concentrations, ratings of cocaine “high”, and heart rate; 3) acute tolerance to the subjective and heart rate effects of cocaine was observed; 4) when combined with cocaine, ethanol led to the slow formation of cocaethylene in amounts much lower than those of its parent compound; and 5) the appearance of cocaethylene in plasma did not alter cocaine's subjective and cardiovascular effects.
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影响因子：
4.2
作者：
GRANT, BF;HARFORD, TC
通讯作者：
HARFORD, TC
影响因子：
2.5
作者：
HIME, GW;HEARN, WL;COFINO, J
通讯作者：
COFINO, J
影响因子：
4.6
作者：
QU, MH;ZHANG, YJ;TOMPKINS, WJ
通讯作者：
TOMPKINS, WJ
用于量化和评估酒精消耗量的分析工具。
DOI：
--
发表时间：
1978
期刊：
Journal of Studies on Alcohol
影响因子：
--
作者：
K. Khavari;P. D. Farber
通讯作者：
P. D. Farber
乙醇和右旋苯丙胺之间的相互作用：对精神运动表现的影响。
DOI：
10.1111/j.1530-0277.1992.tb00640.x
发表时间：
1992
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Perez-Reyes,M;White,WR;McDonald,SA;Hicks,RE
通讯作者：
Hicks,RE