Optimized workplace risk mitigation measures for SARS-CoV-2 in 2022.
Optimized workplace risk mitigation measures for SARS-CoV-2 in 2022.
复制标题
DOI：
10.1038/s41598-023-29087-w
复制
发表时间：
2023-02-16
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
报告了5.96亿例SARS-CoV-2病例，接种了120多亿剂疫苗。随着疫苗接种率的提高，关于工作场所COVID-19预防措施升级和降级的适当阈值的知识存在差距。我们开展了133056次模拟实验，评估了SARS-CoV-2病毒在社区感染的假设工作环境中的传播情况。我们根据应用隔离策略、社区感染率、检测方法和量表、非药物干预、变异优势、疫苗接种覆盖率和疫苗接种效果测试了工作场所获得性感染率。当75%的劳动力接种了有效率为70%的感染疫苗时，当每10万人的社区感染率≤1时，就不需要掩蔽或常规检测+隔离策略来预防工作场所获得性组粒变异感染。在相同的情况下，CIR≤30和≤120将分别导致delta和alpha变体的工作场所获得性感染。100%接种疫苗的劳动力可以预防社区感染率较高的工作场所获得性感染。与使用周转时间较慢的聚合酶链反应方法进行检测相比，使用基于抗原的SARS-CoV-2检测方法识别和隔离工人的工作场所获得性感染相同或更少。可根据社区感染水平、工作人员免疫接种水平和风险承受能力，放宽或加强戴口罩、检测和隔离等风险迁移措施。我们提供的交互式热图可用于即时的、基于参数的病例数预测，为机构政策制定提供信息。我们所描述的模拟方法可以进一步用于未来评估缓解COVID-19传播的策略。
596 million SARS-CoV-2 cases have been reported and over 12 billion vaccine doses have been administered. As vaccination rates increase, a gap in knowledge exists regarding appropriate thresholds for escalation and de-escalation of workplace COVID-19 preventative measures. We conducted 133,056 simulation experiments, evaluating the spread of SARS-CoV-2 virus in hypothesized working environments subject to COVID-19 infections from the community. We tested the rates of workplace-acquired infections based on applied isolation strategies, community infection rates, methods and scales of testing, non-pharmaceutical interventions, variant predominance, vaccination coverages, and vaccination efficacies. When 75% of a workforce is vaccinated with a 70% efficacious vaccine against infection, then no masking or routine testing + isolation strategies are needed to prevent workplace-acquired omicron variant infections when the community infection rate per 100,000 persons is ≤ 1. A CIR ≤ 30, and ≤ 120 would result in no workplace-acquired infections in this same scenario against the delta and alpha variants, respectively. Workforces with 100% worker vaccination can prevent workplace-acquired infections with higher community infection rates. Identifying and isolating workers with antigen-based SARS-CoV-2 testing methods results in the same or fewer workplace-acquired infections than testing with slower turnaround time polymerase chain reaction methods. Risk migration measures such as mask-wearing, testing, and isolation can be relaxed, or escalated, in commensurate with levels of community infections, workforce immunization, and risk tolerance. The interactive heatmap we provide can be used for immediate, parameter-based case count predictions to inform institutional policy making. The simulation approach we have described can be further used for future evaluation of strategies to mitigate COVID-19 spread.
登录
查看更多内容
DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
影响因子：
8.5
作者：
Boon-Itt S;Skunkan Y
通讯作者：
Skunkan Y
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
利物浦无症状测试试验中的Innova SARS-COV-2抗原快速横向流程测试：基于人群的同类研究。
DOI：
10.1136/bmj.n1637
发表时间：
2021-07-06
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
García-Fiñana M;Hughes DM;Cheyne CP;Burnside G;Stockbridge M;Fowler TA;Fowler VL;Wilcox MH;Semple MG;Buchan I
通讯作者：
Buchan I
影响因子：
16.6
作者：
通讯作者：
--