J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging.
J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging.
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用于 NIR-II 成像的内消旋-[2.2]对环芳基-BODIPY 染料的 J-聚集体
DOI：
10.1038/s41467-021-22686-z
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发表时间：
2021-04-22
影响因子：
16.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Li K;Duan X;Jiang Z;Ding D;Chen Y;Zhang GQ;Liu Z
J-聚集是开发第二近红外窗口荧光显像剂的有效策略。然而，由于缺乏合适的J聚集染料，第二近红外荧光J聚集体的设计是具有挑战性的。在此，我们报告meso-[2.2]paracyclophanyl-3，5-bis-N，N-dimethylaminostyrl BODIPY（PCP-BDP 2）作为具有J-聚集诱导的第二近红外荧光的BODIPY染料的实例。PCP-BDP 2在J-聚集态下在1010 nm处显示出最大发射。机理研究表明，PCP基团对BODIPY的空间位阻和共轭效应对J聚集行为和物理性质的调节起着关键作用。值得注意的是，PCP-BDP 2 J-聚集体可用于裸鼠的淋巴结成像和荧光引导手术，这证明了其潜在的临床应用。本研究证明BODIPY染料作为开发第二种近红外成像剂的替代J-聚集平台。J-聚集体已被证明是一种有效的策略，用于开发荧光成像剂在近红外-II光谱区域，但适当的J-聚集体的设计是具有挑战性的。在这里，作者证明了具有NIR-II发射的BODIPY染料的J聚集，并证明了用于荧光引导手术的淋巴结成像。
J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents. J-aggregation has been proved to be an efficient strategy for the development of fluorescent imaging agents in the NIR-II spectral region but the design of appropriate J-aggregates is challenging. Here, the authors demonstrate J-aggregation of a BODIPY dye with NIR-II emission and demonstrate lymph node imaging for fluorescence guided surgery.
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