Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis.
Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis.
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DOI：
10.1186/s40001-023-01280-7
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发表时间：
2023-08-30
影响因子：
4.2
通讯作者：
Zhang, Dan
中科院分区：
文献类型：
--
作者：
Chen, Jian-Peng;Zhang, Yan-Ye;Jin, Jia-Ni;Ying, Yue;Song, Zhi-Min;Xu, Qi-Qi;Tu, Mi-Xue;Ye, Xiao-Hang;Tang, Huan-Na;Ni, Fei-Da;Ying, Yan-Yun;Li, Jing-Yi;Zhang, Dan
子宫内膜异位症与全身代谢指标相关，包括体重指数（BMI）、糖代谢和脂质代谢，但代谢指标与子宫内膜异位症发生和辅助生殖技术（ART）结局之间的关系尚不清楚。我们的目的是评估子宫内膜异位症不孕患者的全身代谢指标特征及其对ART治疗后妊娠结局的影响。一项回顾性队列研究涉及 412 名子宫内膜异位症患者和 1551 名对照者。主要结果是代谢指标，次要指标包括代谢指标对取出的卵母细胞数量和 ART 结果的影响。子宫内膜异位症患者胰岛素（INS）较高[6.90（5.10-9.50）vs 6.50（4.80-8.90）μU/mL，P = 0.005]。结合既往妊娠次数、CA125、空腹血糖 (Glu) 和 INS 的子宫内膜异位症预测模型的敏感性为 73.9%，特异性为 67.8%，曲线下面积 (AUC) 为 0.77。妊娠期间 ART 的结局和并发症没有显着差异。子宫内膜异位症组（aOR 12.95，95% CI 1.69~99.42，P = 0.014）和对照组（aOR 4.15，95% CI 1.50~11.53，P = 0.006）孕前血清Glu水平与GDM相关。我们发现对照组血清Glu与取出卵母细胞数量相关，子宫内膜异位组血清INS与取出卵母细胞数量相关，而两组孕前血清Glu和INS与GDM的发生相关。建立了基于代谢指标的预测模型，代表了一种有前途的非侵入性方法来预测已知妊娠史的子宫内膜异位症患者。在线版本包含可在 10.1186/s40001-023-01280-7 获取的补充材料。
Endometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is unclear. We aimed to evaluate the characteristics of systemic metabolic indexes of endometriosis patients with infertility and their effects on pregnancy outcome after ART treatment. A retrospective cohort study involve 412 endometriosis patients and 1551 controls was conducted. Primary outcome was metabolic indexes, and secondary measures consisted of the influence of metabolic indexes on the number of retrieved oocytes and ART outcomes. Endometriosis patients had higher insulin (INS) [6.90(5.10–9.50) vs 6.50(4.80–8.90) μU/mL, P = 0.005]. A prediction model for endometriosis combining the number of previous pregnancies, CA125, fasting blood glucose (Glu) and INS, had a sensitivity of 73.9%, specificity of 67.8% and area under curve (AUC) of 0.77. There were no significant differences in ART outcomes and complications during pregnancy. The serum levels of Glu before pregnancy were associated with GDM both in endometriosis group (aOR 12.95, 95% CI 1.69–99.42, P = 0.014) and in control group (aOR 4.15, 95% CI 1.50–11.53, P = 0.006). We found serum Glu is related to the number of retrieved oocytes in control group, serum INS is related to the number of retrieved oocytes in endometriosis group, while serum Glu and INS before pregnancy are related to the occurrence of GDM in two groups. A prediction model based on metabolic indexes was established, representing a promising non-invasive method to predict endometriosis patients with known pregnancy history. The online version contains supplementary material available at 10.1186/s40001-023-01280-7.
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影响因子：
4.6
作者：
Dutta M;Singh B;Joshi M;Das D;Subramani E;Maan M;Jana SK;Sharma U;Das S;Dasgupta S;Ray CD;Chakravarty B;Chaudhury K
通讯作者：
Chaudhury K
子宫内膜异位和高胆固醇血症或高血压之间的关联。
DOI：
10.1161/hypertensionaha.117.09056
发表时间：
2017-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Mu F;Rich-Edwards J;Rimm EB;Spiegelman D;Forman JP;Missmer SA
通讯作者：
Missmer SA
影响因子：
--
作者：
Miller JE;Ahn SH;Monsanto SP;Khalaj K;Koti M;Tayade C
通讯作者：
Tayade C
影响因子：
4.1
作者：
Dinsdale NL;Crespi BJ
通讯作者：
Crespi BJ
影响因子：
--
作者：
Marianna, Santonastaso;Alessia, Pucciarelli;Emilio, Chiosi
通讯作者：
Emilio, Chiosi