Tissue-Based Biomarkers for the Risk Stratification of Men With Clinically Localized Prostate Cancer.
Tissue-Based Biomarkers for the Risk Stratification of Men With Clinically Localized Prostate Cancer.
复制标题
DOI：
10.3389/fonc.2021.676716
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Hu JC
中科院分区：
文献类型：
--
作者：
Basourakos SP;Tzeng M;Lewicki PJ;Patel K;Al Hussein Al Awamlh B;Venkat S;Shoag JE;Gorin MA;Barbieri CE;Hu JC
临床局限性前列腺癌男性的风险分层历来依赖于基本的临床病理参数，例如前列腺特异性抗原水平、分级组和临床分期。然而，前列腺癌的表现通常无法通过这些参数准确预测。因此，最近的工作重点是开发基于组织的基因组测试，以更深入地了解特定患者疾病的风险。多种测试现已投入商业使用，并在前列腺癌治疗路径的各个阶段提供额外的预后信息。事实上，早期证据表明这些检测可能对患者和医生的决策产生重大影响。然而，这些测试对肿瘤学结果的影响仍不清楚。在这篇综述中，我们重点介绍了使用基于组织的生物标志物治疗前列腺癌的最新进展，并确定了支持其临床使用的现有证据。
Risk stratification of men with clinically localized prostate cancer has historically relied on basic clinicopathologic parameters such as prostate specific antigen level, grade group, and clinical stage. However, prostate cancer often behaves in ways that cannot be accurately predicted by these parameters. Thus, recent efforts have focused on developing tissue-based genomic tests that provide greater insights into the risk of a given patient’s disease. Multiple tests are now commercially available and provide additional prognostic information at various stages of the care pathway for prostate cancer. Indeed, early evidence suggests that these assays may have a significant impact on patient and physician decision-making. However, the impact of these tests on oncologic outcomes remains less clear. In this review, we highlight recent advances in the use of tissue-based biomarkers in the treatment of prostate cancer and identify the existing evidence supporting their clinical use.
登录
查看更多内容
影响因子：
4.8
作者：
Den, R. B.;Santiago-Jimenez, M.;Shah, N. L.
通讯作者：
Shah, N. L.
影响因子：
51.1
作者：
Cuzick, Jack;Swanson, Gregory P.;Fisher, Gabrielle;Brothman, Arthur R.;Berney, Daniel M.;Reid, Julia E.;Mesher, David;Speights, V. O.;Stankiewicz, Elzbieta;Foster, Christopher S.;Moller, Henrik;Scardino, Peter;Warren, Jorja D.;Park, Jimmy;Younus, Adib;Flake, Dart D., II;Wagner, Susanne;Gutin, Alexander;Lanchbury, Jerry S.;Stone, Steven
通讯作者：
Stone, Steven
影响因子：
23.4
作者：
Cooperberg, Matthew R.;Davicioni, Elai;Crisan, Anamaria;Jenkins, Robert B.;Ghadessi, Mercedeh;Karnes, R. Jeffrey
通讯作者：
Karnes, R. Jeffrey
DOI：
10.1016/j.ijrobp.2018.08.030
发表时间：
2019-01-01
影响因子：
7
作者：
Berlin, Alejandro;Murgic, Jure;Chua, Melvin L. K.
通讯作者：
Chua, Melvin L. K.
影响因子：
120.7
作者：
EPSTEIN, JI;WALSH, PC;BRENDLER, CB
通讯作者：
BRENDLER, CB