Quality of life measures and health utility values among dry eye subgroups.
Quality of life measures and health utility values among dry eye subgroups.
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DOI：
10.1186/s12955-018-0999-3
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发表时间：
2018-08-31
影响因子：
3.6
通讯作者：
DECS-J study group
中科院分区：
文献类型：
--
作者：
Shigeyasu C;Yamada M;Kawashima M;Suwaki K;Uchino M;Hiratsuka Y;Yokoi N;Tsubota K;DECS-J study group
为了确定干眼（DE）患者的生活质量（QOL）和健康效用是否受到相同程度的影响，具有最小临床症状的短泪膜破裂时间干眼（TBUT-DE）与缺水性干眼（ADDE）的严重程度相同。一项多中心横断面研究在日本10家眼科诊所就诊的DE患者中进行。在463例注册患者中，本研究涉及449例年龄在20岁及以上的DE患者。评估眼科检查结果，包括泪膜破裂时间（TBUT）、Schirmer I值和角膜结膜染色评分。使用干眼相关生活质量评分（DEQS； 0[最好]，100[最差]）和健康效用（1[总健康]，0[最差]）评估生活质量，健康效用指数标记为3 (HUI-3)；评分按DE亚组分层。所有参与者的DEQS和HUI-3得分中位数（四分位数范围）分别为21.7（10.0-40.0）和0.82（0.69-0.91）。ADDE组DEQS和HUI-3评分中位数（四分位间距）分别为23.3（10.0 ~ 40.0）和0.79 (0.69 ~ 0.88)；短TBUT-DE组分别为23.3（13.3-38.3）和0.82（0.74-0.92）。问卷得分组间差异无统计学意义。眼科检查结果中，TBUT、角膜染色评分、角膜结膜染色评分与DEQS呈弱显著相关；观察了HUI-3的TBUT和Schirmer检验值。DEQS和HUI-3评估的短TBUT-DE对生活质量的负担与ADDE一样严重。我们的研究结果表明，临床医生应该意识到短TBUT-DE对患者生活质量和效用价值的影响。大学医院医疗信息网(注册号：UMIN 000015890)。注册于2014年12月10日，追溯注册。
To determine whether quality of life (QOL) and health utility are affected to the same extent among dry eye (DE) patients with short tear film break-up time dry eye (TBUT-DE) with minimal clinical signs were as severe as aqueous-deficient dry eye (ADDE). A multicenter cross-sectional study was conducted among DE patients who visited one of 10 eye clinics in Japan. Among the 463 registered patients, this study involved 449 patients with DE who were aged 20 years or older. Ophthalmic examination findings were assessed, including tear film break-up time (TBUT), Schirmer I value, and keratoconjunctival staining score. QOL was evaluated with the Dry Eye-Related Quality-of-Life Score (DEQS; 0 [best], 100 [worst]) and health utility (1 [total health], 0 [worst]) with the Health Utilities Index Mark 3 (HUI-3); scores were stratified by DE subgroup. Median (interquartile range) of DEQS and HUI-3 scores across all participants were 21.7 (10.0–40.0) and 0.82 (0.69–0.91), respectively. Median (interquartile range) DEQS and HUI-3 scores in the ADDE group were 23.3 (10.0–40.0) and 0.79 (0.69–0.88), respectively; those in the short TBUT-DE group were 23.3 (13.3–38.3) and 0.82 (0.74–0.92), respectively. There were no significant between-group differences in questionnaire scores. Among the ophthalmic examination findings, a weak significant correlation between TBUT, corneal staining score and keratoconjunctival staining score to DEQS; TBUT and Schirmer test values to HUI-3, were seen. The burden of short TBUT-DE on QOL as assessed by the DEQS and HUI-3 was as severe as that in ADDE. Our findings suggest that clinicians should be aware of the impact of short TBUT-DE on patients QOL and utility values. University Hospital Medical Information Network (registration no. UMIN 000015890). Registered 10th December 2014, retrospectively registered.
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通讯作者：
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