Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality.
Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality.
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DOI：
10.1146/annurev.anchem.1.031207.112942
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Muddiman DC
中科院分区：
文献类型：
--
作者：
Hawkridge AM;Muddiman DC
Biomarker discovery and proteomics have become synonymous with mass spectrometry in recent years. Although this conflation is an injustice to the many essential biomolecular techniques widely used in biomarker-discovery platforms, it underscores the power and potential of contemporary mass spectrometry. Numerous novel and powerful technologies have been developed around mass spectrometry, proteomics, and biomarker discovery over the past 20 years to globally study complex proteomes (e.g., plasma). However, very few large-scale longitudinal studies have been carried out using these platforms to establish the analytical variability relative to true biological variability. The purpose of this review is not to cover exhaustively the applications of mass spectrometry to biomarker discovery, but rather to discuss the analytical methods and strategies that have been developed for mass spectrometry–based biomarker-discovery platforms and to place them in the context of the many challenges and opportunities yet to be addressed.
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3.4
作者：
FAWCETT, JK;WYNN, V
通讯作者：
WYNN, V
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Petricoin, Emanuel F 3rd
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作者：
FENN, JB;MANN, M;WHITEHOUSE, CM
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WHITEHOUSE, CM
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作者：
ELIN, RJ
通讯作者：
ELIN, RJ
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作者：
Davidsson P;Sjögren M
通讯作者：
Sjögren M