History of allergic disease and risk of meningioma.
History of allergic disease and risk of meningioma.
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过敏性疾病史和脑膜瘤风险。
DOI：
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发表时间：
2006
影响因子：
5
通讯作者：
P. McKinney
中科院分区：
文献类型：
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作者：
M. Schoemaker;A. Swerdlow;S. Hepworth;M. Tongeren;Kenneth W. Muir;P. McKinney
流行病学研究一致表明过敏性疾病与神经胶质瘤风险呈负相关，但尚不清楚这种相关性是否也适用于脑膜瘤。作者根据英国两项基于人群的病例对照研究（2001-2004 年）的数据，对与过敏性疾病史相关的脑膜瘤风险进行了汇总分析，该研究涉及 475 例病例和 1,716 名对照者。与自我报告、医生诊断的过敏性疾病相比，脑膜瘤风险显着降低（比值比 = 0.76，95% 置信区间 (CI)：0.61，0.96），但对于个别情况：哮喘（比值比 = 0.85，95% CI：0.61，1.18）、花粉热（比值比 = 0.81，95% CI：0.62，1.06）和湿疹（比值比 = 0.72，95% CI：0.51，1.02）。发病年龄较早（<10 岁）的哮喘（比值比 = 0.43，95% CI：0.21，0.89）和花粉热（比值比 = 0.50，95% CI：0.25，1.00）和湿疹（比值比 = 0.46，95% CI：0.21）的风险降低幅度最大。 1.07) 发病年龄为 10-19 岁；他们在成年期的发病时间接近一致。这项研究表明，过敏史与脑膜瘤风险之间存在负相关，但风险降低幅度小于神经胶质瘤。这种关联的原因需要澄清，以及病因学解释。还需要考虑混杂或偏见。
Epidemiologic studies have consistently shown inverse associations of allergic disease with risk of glioma, but it is unclear whether this association also applies to meningioma. The authors conducted a pooled analysis of meningioma risk in relation to a history of allergic disease based on data from two population-based, case-control studies with 475 cases and 1,716 controls in the United Kingdom (2001-2004). Meningioma risk was significantly reduced in relation to self-reported, physician-diagnosed allergic disease (odds ratio = 0.76, 95% confidence interval (CI): 0.61, 0.96) but was nonsignificantly reduced for individual conditions: asthma (odds ratio = 0.85, 95% CI: 0.61, 1.18), hay fever (odds ratio = 0.81, 95% CI: 0.62, 1.06), and eczema (odds ratio = 0.72, 95% CI: 0.51, 1.02). Risk reductions were greatest for asthma (odds ratio = 0.43, 95% CI: 0.21, 0.89) and hay fever (odds ratio = 0.50, 95% CI: 0.25, 1.00) with an early age at onset (<10 years) and for eczema (odds ratio = 0.46, 95% CI: 0.21, 1.07) with an onset at ages 10-19 years; they were near unity for onset in adulthood. This study suggests an inverse association between a history of allergies and meningioma risk, but with smaller risk reductions than for glioma. The reasons for this association need clarification, as well as an etiologic explanation. Consideration also needs to be given to confounding or bias.
影响因子：
14.2
作者：
Miranda, C;Busacker, A;Wenzel, SE
通讯作者：
Wenzel, SE