The RhoA dependent anti-metastatic function of RKIP in breast cancer.
The RhoA dependent anti-metastatic function of RKIP in breast cancer.
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DOI：
10.1038/s41598-021-96709-6
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发表时间：
2021-08-31
影响因子：
4.6
通讯作者：
Yeung KC
中科院分区：
文献类型：
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作者：
Kalpana G;Figy C;Feng J;Tipton C;De Castro JN;Bach VN;Borile C;LaSalla A;Odeh HN;Yeung M;Garcia-Mata R;Yeung KC
Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis. Yet, the molecular mechanism through which RKIP executes its effects is not completely defined. RhoA has both a pro- and anti-metastatic cell-context dependent functions. Given that Rho GTPases primarily function on actin cytoskeleton dynamics and cell movement regulation, it is possible that one way RKIP hinders cancer cell invasion/metastasis is by targeting these proteins. Here we show that RKIP inhibits cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activates RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.
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影响因子：
30.8
作者：
Palomero, Teresa;Couronne, Lucile;Khiabanian, Hossein;Kim, Mi-Yeon;Ambesi-Impiombato, Alberto;Perez-Garcia, Arianne;Carpenter, Zachary;Abate, Francesco;Allegretta, Maddalena;Haydu, J. Erika;Jiang, Xiaoyu;Lossos, Izidore S.;Nicolas, Concha;Balbin, Milagros;Bastard, Christian;Bhagat, Govind;Piris, Miguel A.;Campo, Elias;Bernard, Olivier A.;Rabadan, Raul;Ferrando, Adolfo A.
通讯作者：
Ferrando, Adolfo A.
影响因子：
11.2
作者：
Frankenberger C;Rabe D;Bainer R;Sankarasharma D;Chada K;Krausz T;Gilad Y;Becker L;Rosner MR
通讯作者：
Rosner MR
影响因子：
11.2
作者：
Humphries, Brock;Wang, Zhishan;Yang, Chengfeng
通讯作者：
Yang, Chengfeng
影响因子：
11.2
作者：
Al-Mulla, Fahd;Bitar, Milad S.;Kolch, Walter
通讯作者：
Kolch, Walter
影响因子：
--
作者：
Datar I;Qiu X;Ma HZ;Yeung M;Aras S;de la Serna I;Al-Mulla F;Thiery JP;Trumbly R;Fan X;Cui H;Yeung KC
通讯作者：
Yeung KC