Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura.
Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura.
复制标题
DOI：
10.3389/fnins.2022.825172
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Wang X;Zhang Y;Qi W;Xu T;Wang Z;Liao H;Wang Y;Liu J;Yu Y;He Z;Gao S;Li D;Zhang G;Zhao L
偏头痛是一种与复杂大脑活动相关的原发性神经系统疾病。最近，越来越多的证据表明，偏头痛是由异常的动态大脑活动的特点是线性和非线性变化跨越各种时间尺度的基础。然而，无先兆偏头痛（MWoA）患者在不同时间尺度上的异常动态脑活动仍然是未知的。本研究旨在评估不同时间尺度上脑活动动力学的改变模式以及MWoA患者改变的潜在病理生理学机制。计算50例患者和20例健康对照者（HC）的多尺度熵，以研究5个不同时间尺度上的模式和改变的大脑复杂性（BC）。显示显著组间差异的区域中BC与临床评分之间的斯皮尔曼等级相关分析（即，偏头痛发作频率、持续时间、头痛冲击试验）。BC的空间分布在不同的时间尺度上有所不同。在时间尺度1，BC在参与者的后验默认模式网络（DMN）中较高。与HC相比，MWoA患者在DMN和感觉运动网络中具有更高的BC。在时间尺度2，BC主要是较高的前DMN的参与者。MWoA患者在感觉运动网络中具有较高的BC。在时间尺度3，BC主要是较高的额顶叶网络的参与者。MWoA患者的顶回BC增加。在时间尺度4，BC主要是较高的感觉运动网络。MWoA患者在中央后回有较高的BC。在时间尺度5，BC主要是较高的DMN。MWoA患者的后DMN BC较低。尤其是楔前叶和中央旁小叶的BC值与临床症状显著相关。偏头痛与感觉运动网络和DMN中动态脑活动在多个时间尺度上的改变相关。这些区域内随时间变化的BC可能与疼痛传递和调制的不稳定性有关。我们的研究结果为偏头痛患者脑动态活动异常的假说提供了新的证据。
Migraine is a primary neurological disorder associated with complex brain activity. Recently, mounting evidence has suggested that migraine is underpinned by aberrant dynamic brain activity characterized by linear and non-linear changes across a variety of time scales. However, the abnormal dynamic brain activity at different time scales is still unknown in patients with migraine without aura (MWoA). This study aimed to assess the altered patterns of brain activity dynamics over different time scales and the potential pathophysiological mechanisms of alterations in patients with MWoA. Multiscale entropy in 50 patients and 20 healthy controls (HCs) was calculated to investigate the patterns and altered brain complexity (BC) across five different time scales. Spearman rank correlation analysis between BC in regions showing significant intergroup differences and clinical scores (i.e., frequency of migraine attacks, duration, headache impact test) was conducted in patients with MWoA. The spatial distribution of BC varied across different time scales. At time scale1, BC was higher in the posterior default mode network (DMN) across participants. Compared with HCs, patients with MWoA had higher BC in the DMN and sensorimotor network. At time scale2, BC was mainly higher in the anterior DMN across participants. Patients with MWoA had higher BC in the sensorimotor network. At time scale3, BC was mainly higher in the frontoparietal network across participants. Patients with MWoA had increased BC in the parietal gyrus. At time scale4, BC is mainly higher in the sensorimotor network. Patients with MWoA had higher BC in the postcentral gyrus. At time scale5, BC was mainly higher in the DMN. Patients with MWoA had lower BC in the posterior DMN. In particular, BC values in the precuneus and paracentral lobule significantly correlated with clinical symptoms. Migraine is associated with alterations in dynamic brain activity in the sensorimotor network and DMN over multiple time scales. Time-varying BC within these regions could be linked to instability in pain transmission and modulation. Our findings provide new evidence for the hypothesis of abnormal dynamic brain activity in migraine.
登录
查看更多内容
揭示针灸对偏头痛作用的神经机制：系统评价。
影响因子：
4.3
作者：
Liu L;Tian T;Li X;Wang Y;Xu T;Ni X;Li X;He Z;Gao S;Sun M;Liang F;Zhao L
通讯作者：
Zhao L
DOI：
10.1186/s10194-020-01210-6
发表时间：
2021-01-07
期刊：
The journal of headache and pain
影响因子：
--
作者：
Lim M;Jassar H;Kim DJ;Nascimento TD;DaSilva AF
通讯作者：
DaSilva AF
影响因子：
5.3
作者：
Rogachov, Anton;Cheng, Joshua C.;Davis, Karen D.
通讯作者：
Davis, Karen D.
影响因子：
14.5
作者：
Bornhövd, K;Quante, M;Büchel, C
通讯作者：
Büchel, C
影响因子：
7.4
作者：
May, Arne
通讯作者：
May, Arne