Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine.
Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine.
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DOI：
10.1186/s10194-020-01210-6
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发表时间：
2021-01-07
期刊：
影响因子：
--
通讯作者：
DaSilva AF
中科院分区：
文献类型：
--
作者：
Lim M;Jassar H;Kim DJ;Nascimento TD;DaSilva AF
研究表明，静息状态下大脑活动的每时每刻的变化在慢性疼痛中发挥着积极作用。在这里，我们研究了偏头痛发作间期的区域血氧水平依赖性信号变异性（BOLDSV）和区域间动态功能连接性（dFC）及其与发作严重程度的关系。我们采集了 20 名偏头痛患者和 26 名健康对照 (HC) 的静息态功能磁共振成像。我们计算了每个体素处 BOLD 时间序列的标准差 (SD)，作为 BOLD 信号变异性 (BOLDSV) 的度量，并进行了全脑体素组比较。 BOLDSV 中显示显着组间差异的大脑区域用于定义感兴趣区域 (ROI)。计算这些 ROI 之间动态条件相关性的 SD 和平均值，以测量 dFC 的变异性和强度。此外，还评估了偏头痛发作期患者的实验疼痛阈值和头痛面积/强度水平的临床相关性。我们发现，与正常人相比，偏头痛患者在三叉神经脊髓-丘脑-皮质上行通路中表现出更大的 BOLDSV，包括三叉神经脊髓核、丘脑枕核/腹侧后内侧 (VPM) 核、初级体感皮层 (S1) 和后岛叶。相反，与 HC 相比，偏头痛患者在自上而下的调节通路中表现出较低的 BOLDSV，包括背外侧前额叶 (dlPFC) 和下顶叶 (IPC) 皮质。重要的是，三叉神经脊髓-丘脑-皮质和额顶叶上行通路的发作间期异常 BOLDSV 与偏头痛发作期间患者的头痛严重程度和热痛敏感性相关。与正常人相比，偏头痛患者的丘脑皮质通路 (VPM-S1) 内的 dFC 变异性显着降低，强度也更高。相比之下，偏头痛患者额顶通路 (dlPFC-IPC) 内的 dFC 表现出更大的变异性和更低的强度。偏头痛与上行三叉神经体感和自上而下调节通路的时间信号变异性改变有关，这可以解释偏头痛相关的疼痛和异常性疼痛。丘脑皮质和额顶叶通路内随时间变化的连接模式的对比可能与疼痛传递和调节的异常网络完整性和不稳定性有关。
The moment-to-moment variability of resting-state brain activity has been suggested to play an active role in chronic pain. Here, we investigated the regional blood-oxygen-level-dependent signal variability (BOLDSV) and inter-regional dynamic functional connectivity (dFC) in the interictal phase of migraine and its relationship with the attack severity. We acquired resting-state functional magnetic resonance imaging from 20 migraine patients and 26 healthy controls (HC). We calculated the standard deviation (SD) of the BOLD time-series at each voxel as a measure of the BOLD signal variability (BOLDSV) and performed a whole-brain voxel-wise group comparison. The brain regions showing significant group differences in BOLDSV were used to define the regions of interest (ROIs). The SD and mean of the dynamic conditional correlation between those ROIs were calculated to measure the variability and strength of the dFC. Furthermore, patients’ experimental pain thresholds and headache pain area/intensity levels during the migraine ictal-phase were assessed for clinical correlations. We found that migraineurs, compared to HCs, displayed greater BOLDSV in the ascending trigeminal spinal-thalamo-cortical pathways, including the spinal trigeminal nucleus, pulvinar/ventral posteromedial (VPM) nuclei of the thalamus, primary somatosensory cortex (S1), and posterior insula. Conversely, migraine patients exhibited lower BOLDSV in the top-down modulatory pathways, including the dorsolateral prefrontal (dlPFC) and inferior parietal (IPC) cortices compared to HCs. Importantly, abnormal interictal BOLDSV in the ascending trigeminal spinal-thalamo-cortical and frontoparietal pathways were associated with the patient’s headache severity and thermal pain sensitivity during the migraine attack. Migraineurs also had significantly lower variability and greater strength of dFC within the thalamo-cortical pathway (VPM-S1) than HCs. In contrast, migraine patients showed greater variability and lower strength of dFC within the frontoparietal pathway (dlPFC-IPC). Migraine is associated with alterations in temporal signal variability in the ascending trigeminal somatosensory and top-down modulatory pathways, which may explain migraine-related pain and allodynia. Contrasting patterns of time-varying connectivity within the thalamo-cortical and frontoparietal pathways could be linked to abnormal network integrity and instability for pain transmission and modulation.
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影响因子：
7.4
作者：
Bjork, Marte Helene;Stovner, Lars J.;Sand, Trond
通讯作者：
Sand, Trond
影响因子：
9.9
作者：
Coppola, Gianluca;Di Renzo, Antonio;Pierelli, Francesco
通讯作者：
Pierelli, Francesco
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
9.9
作者：
DaSilva, Alexandre F. M.;Granziera, Cristina;Hadjikhani, Nouchine
通讯作者：
Hadjikhani, Nouchine
影响因子：
5.7
作者：
Cheng, J. C.;Bosma, R. L.;Davis, K. D.
通讯作者：
Davis, K. D.