The mycobiota: interactions between commensal fungi and the host immune system.

The mycobiota: interactions between commensal fungi and the host immune system.
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DOI:
10.1038/nri3684
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发表时间:
2014-06
期刊:
Nature reviews. Immunology
影响因子:
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中科院分区:
其他
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人体是各种各样的微生物群落的宿主,免疫系统需要保护我们免受微生物群落的影响,这些微生物群落对于正常的免疫系统发展和维持健康的组织和生理过程非常重要。研究人员在很大程度上集中在这些群落的细菌成员上,但越来越多的研究强调了真菌的存在,这可能对定义群落及其与免疫细胞的相互作用很重要。在这篇综述中,我们讨论了目前已知的关于身体上真菌群落的组成和免疫系统的特征,这些特征对于在这些部位与真菌相互作用特别重要。
The body is host to a wide variety of microbial communities from which the immune system needs to protect us and which are important for normal immune system development and maintenance of healthy tissues and physiological processes. Investigators have largely focused on the bacterial members of these communities, but an increasing number of studies underscore the presence of fungi as well that may be important for defining the communities and their interactions with immune cells. In this Review we discuss what is currently known about the makeup of fungal communities on the body and features of the immune system that are particularly important for interacting with fungi at these sites.
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