Association of chorioamnionitis and patent ductus arteriosus in a national U.S. cohort.
Association of chorioamnionitis and patent ductus arteriosus in a national U.S. cohort.
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DOI：
10.1038/s41372-020-00866-x
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Venkatesh KK
中科院分区：
文献类型：
--
作者：
Green CA;Westreich D;Laughon MM;Stamilio DM;Strauss RA;Reese J;Shelton EL;Venkatesh KK
评估临床绒毛膜炎对动脉导管未闭（PDA）风险的影响。美国安全分娩联盟（CSL）研究中所有>23孕周分娩的次要分析。初次暴露为绒毛膜炎的临床诊断，结局为PDA的诊断。利用广义估计方程估计误差方差的妇女多产。校正了年龄、种族、地区、分娩年份、体重指数、婴儿性别、多胎妊娠、分娩方式和产前皮质类固醇暴露的模型。在228，438例分娩中，有绒毛膜炎暴露的PDA诊断率高于无绒毛膜炎暴露的PDA诊断率（9.2% vs. 3.0%; OR：3.25; 95% CI：2.92-3.62）。绒毛膜炎与PDA的调整后几率较高相关（AOR：2.18; 95%CI：1.93-2.45）。在敏感性分析中，调整分娩时胎龄后，绒毛膜炎和PDA之间的相关性仍然存在（AOR：1.28; 95%CI：1.13-1.44）。绒毛膜炎与PDA发生几率增加相关。为了进一步研究这种流行病学相关性，需要对混杂因素进行仔细评估，并进行稳健的暴露和结局确定。
To estimate the effect of clinical chorioamnionitis on the risk of patent ductus arteriosus (PDA). A secondary analysis of all deliveries >23 gestational weeks from the U.S. Consortium on Safe Labor (CSL) study. The primary exposure was a clinical diagnosis of chorioamnionitis, and the outcome was a diagnosis of PDA. Generalized estimating equations with estimated error variance for women with multiple deliveries were utilized. Models adjusted for age, race, region, delivery year, body mass index, infant sex, multiple gestation, mode of delivery, and antenatal corticosteroid exposure. Among 228,438 deliveries, a diagnosis of PDA was more frequent with chorioamnionitis exposure versus without (9.2% vs. 3.0%; OR: 3.25; 95% CI: 2.92–3.62). Chorioamnionitis was associated with higher adjusted odds of PDA (AOR: 2.18; 95% CI: 1.93–2.45). In sensitivity analyses, the association between chorioamnionitis and PDA held after adjustment for gestational age at delivery (AOR: 1.28; 95% CI: 1.13–1.44). Chorioamnionitis was associated with increased odds of PDA. Robust exposure and outcome ascertainment with careful assessment of confounding is needed to further investigate this epidemiologic association.
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影响因子：
9.8
作者：
Ananth CV;Schisterman EF
通讯作者：
Schisterman EF
DOI：
10.3109/14767058.2013.850668
发表时间：
2014-07-01
影响因子：
1.8
作者：
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作者：
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影响因子：
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作者：
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McElhinney, Doff B.
影响因子：
2.1
作者：
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