Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation.
Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation.
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DOI：
10.1126/sciimmunol.aal5068
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发表时间：
2017-07-21
影响因子：
24.8
通讯作者：
Hsieh CS
中科院分区：
文献类型：
--
作者：
Chai JN;Peng Y;Rengarajan S;Solomon BD;Ai TL;Shen Z;Perry JSA;Knoop KA;Tanoue T;Narushima S;Honda K;Elson CO;Newberry RD;Stappenbeck TS;Kau AL;Peterson DA;Fox JG;Hsieh CS
特定的肠道寄生菌通过引发互惠调节性T（Treg）细胞反应来改善宿主健康。然而，在炎症期间诱导效应T（Teff）细胞的细菌尚不清楚。在这里，我们通过分析小鼠结肠炎模型中的细菌反应性TCR转基因细胞和TCR库来解决这个问题。出乎意料的是，我们发现粘膜相关的螺杆菌物种在稳态期间触发Treg应答，在结肠炎期间触发Teff应答，如Teff/Treg TCR库与结肠炎之间的重叠增加所表明的。事实上，测试的4/6 Treg TCR在体外和体内识别粘膜相关螺杆菌物种。相比之下，在结肠炎期间观察到的管腔拟杆菌属物种的显著扩张并未引发相称的Teff反应。与其他诱导Treg细胞的细菌不同，螺杆菌是已知的致病菌，并在免疫缺陷小鼠中引起疾病。因此，我们的研究提出了一种模型，其中粘膜细菌引起上下文依赖性Treg或效应细胞反应，以促进肠道耐受或炎症。
Specific gut commensal bacteria improve host health by eliciting mutualistic regulatory T (Treg) cells responses. However, the bacteria that induce effector T (Teff) cells during inflammation are unclear. Here, we addressed this by analyzing bacterial-reactive TCR transgenic cells and TCR repertoires in a murine colitis model. Unexpectedly, we found that mucosal-associated Helicobacter species triggered both Treg responses during homeostasis and Teff responses during colitis, as suggested by an increased overlap between the Teff/Treg TCR repertoires with colitis. In fact, 4/6 Treg TCRs tested recognized mucosal-associated Helicobacter species in vitro and in vivo. By contrast, the marked expansion of luminal Bacteroides species seen during colitis did not trigger a commensurate Teff response. Unlike other Treg cell-inducing bacteria, Helicobacter species are known pathobionts and cause disease in immunodeficient mice. Thus, our study suggests a model in which mucosal bacteria elicit context-dependent Treg or effector cell responses to facilitate intestinal tolerance or inflammation.
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DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
3.3
作者：
Castillo, M;Martín-Orúe, SM;Gasa, J
通讯作者：
Gasa, J
影响因子：
48
作者：
Edgar, Robert C.
通讯作者：
Edgar, Robert C.
影响因子：
29.4
作者：
Calderon-Gomez, Elisabeth;Bassolas-Molina, Helena;Salas, Azucena
通讯作者：
Salas, Azucena