Somatosensory evoked high-frequency oscillations recorded directly from the human cerebral cortex
Somatosensory evoked high-frequency oscillations recorded directly from the human cerebral cortex
复制标题
直接从人类大脑皮层记录的体感诱发高频振荡
DOI：
10.1016/s1388-2457(00)00449-1
复制
发表时间：
2000
影响因子：
4.7
通讯作者：
H. Lüders
中科院分区：
文献类型：
--
作者：
Y. Maegaki;I. Najm;K. Terada;H. Morris;W. Bingaman;N. Kohaya;A. Takenobu;Yoko Kadonaga;H. Lüders
目的为了阐明体感诱发电位（SEP）高频振荡的发生器来源，我们直接记录了来自人类大脑皮层的体感诱发高频振荡。 对象和方法对 7 名患者进行了研究，其中 6 名患有难治性部分性癫痫，1 名患有脑肿瘤。通过长期植入硬膜下电极，我们记录了所有患者对正中神经刺激的 SEP，并记录了一名患者对唇部和胫后神经刺激的 SEP。使用受限带通滤波器（500-2000 Hz）记录高频振荡。结果对于正中神经振荡，所有振荡电位在最接近主要手部感觉运动区域的电极处最大。大多数振荡的分布与 P20/N20 相似或更分散。 P20 或 N20 峰值后的一些后期振荡出现在类似于 P25 的非常有限的皮质区域中。我们研究了中央沟周围每个振荡电位的相位变化。三分之一的振荡显示出中央沟周围的相位反转，而后来在受限皮质区域引起的振荡则没有。对后胫神经和嘴唇的高频振荡在感觉运动区域也达到最大。大多数唇部振荡在中央沟周围出现相位反转，但大多数胫后神经振荡则没有。结论高频振荡在初级感觉运动区附近产生。正中神经高频振荡至少有两种不同的发生器机制。我们怀疑大多数振荡源自丘脑皮质辐射的终末段或靠近 P20/N20 发生器的初级感觉运动皮层，以及一些后来的振荡来自靠近 P25 发生器的浅表皮层。
ObjectiveTo elucidate the generator sources of high-frequency oscillations of somatosensory evoked potentials (SEPs), we recorded somatosensory evoked high-frequency oscillations directly from the human cerebral cortex.Subjects and methodsSeven patients, 6 with intractable partial epilepsy and one with a brain tumor, were studied. With chronically implanted subdural electrodes, we recorded SEPs to median nerve stimulation in all patients, and also recorded SEPs to lip and posterior tibial nerve stimulation in one. High-frequency oscillations were recorded using a restricted bandpass filter (500–2000 Hz).ResultsFor the median nerve oscillations, all oscillation potentials were maximum at the electrodes closest to the primary hand sensorimotor area. Most oscillations were distributed similar to or more diffusely than P20/N20. Some later oscillations after the peak of P20 or N20 were present in a very restricted cortical area similar to P25. We investigated the phase change of each oscillation potential around the central sulcus. One-third of the oscillations showed phase reversal around the central sulcus, while later oscillations elicited in a restricted cortical area did not. High-frequency oscillations to posterior tibial nerve and lip stimulation were also maximum in the sensorimotor areas. Most of the lip oscillations showed phase reversal around the central sulcus, but most of the posterior tibial nerve oscillations did not.ConclusionHigh-frequency oscillations are generated near the primary sensorimotor area. There are at least two different generator mechanisms for the median nerve high-frequency oscillations. We suspect that most oscillations are derived from the terminal segments of thalamocortical radiations or from the primary sensorimotor cortex close to the generator of P20/N20, and some later oscillations from the superficial cortex close to the generator of P25.
DOI：
10.1016/0168-5597(95)00006-e
发表时间：
1995-05-01
期刊：
EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
PETERSON, NN;SCHROEDER, CE;AREZZO, JC
通讯作者：
AREZZO, JC
人手和嘴唇感觉运动皮层的皮层电图研究。
DOI：
10.1016/0168-5597(92)90016-5
发表时间：
1992
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Baumgartner,C;Barth,DS;Levesque,MF;Sutherling,WW
通讯作者：
Sutherling,WW