Changes in histoanatomical distribution of types I, III and V collagen promote adaptative remodeling in posterior tibial tendon rupture.
Changes in histoanatomical distribution of types I, III and V collagen promote adaptative remodeling in posterior tibial tendon rupture.
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DOI：
10.1590/s1807-59322008000100003
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发表时间：
2008-02
期刊：
影响因子：
--
通讯作者：
Yoshinari NH
中科院分区：
文献类型：
--
作者：
Satomi E;Teodoro WR;Parra ER;Fernandes TD;Velosa AP;Capelozzi VL;Yoshinari NH
胫后肌腱功能障碍是成人扁平足畸形的常见原因，其病因不明。在这项研究中，我们的特点是形态学模式和分布的I型，III型和V型胶原在胫骨后肌腱功能障碍。肌腱样本从患者和没有胫骨后肌腱功能障碍进行了染色免疫荧光抗体对I型，III型和V型胶原蛋白。对照样品显示，V型仅沉积在血管附近，而手术获得的标本显示V型胶原蛋白在较厚的外膜层中围绕其他类型的胶原纤维。病理标本中III型胶原水平也增加。另一方面，在病理标本中，占正常肌腱中总胶原含量95%的I型胶原含量减少。由于III型和V型胶原蛋白的较高表达以及I型胶原蛋白的量减少，导致胫骨后肌腱功能障碍中的原纤维形成发生改变，这使得原始原纤维在结构上对机械力的抵抗力降低。
Posterior tibial tendon dysfunction is a common cause of adult flat foot deformity, and its etiology is unknown. In this study, we characterized the morphologic pattern and distribution of types I, III and V collagen in posterior tibial tendon dysfunction. Tendon samples from patients with and without posterior tibial tendon dysfunction were stained by immunofluorescence using antibodies against types I, III and V collagen. Control samples showed that type V deposited near the vessels only, while surgically obtained specimens displayed type V collagen surrounding other types of collagen fibers in thicker adventitial layers. Type III collagen levels were also increased in pathological specimens. On the other hand, amounts of collagen type I, which represents 95% of the total collagen amount in normal tendon, were decreased in pathological specimens. Fibrillogenesis in posterior tibial tendon dysfunction is altered due to higher expression of types III and V collagen and a decreased amount of collagen type I, which renders the originating fibrils structurally less resistant to mechanical forces.
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DOI：
10.2106/00004623-198668010-00012
发表时间：
1986-01-01
影响因子：
5.3
作者：
FUNK, DA;CASS, JR;JOHNSON, KA
通讯作者：
JOHNSON, KA
影响因子：
2.7
作者：
Mosier, SM;Lucas, DR;Manoli, A
通讯作者：
Manoli, A
影响因子：
2.8
作者：
Pufe, T;Petersen, W;Mentlein, R
通讯作者：
Mentlein, R
影响因子：
2.8
作者：
Teodoro, WR;Velosa, AP;Yoshinari, NH
通讯作者：
Yoshinari, NH
DOI：
10.1302/0301-620x.84b1.11592
发表时间：
2002-01-01
影响因子：
--
作者：
Petersen, W;Hohmann, G;Tillmann, B
通讯作者：
Tillmann, B