Analysis of low Reynolds number blood flow in a rectangular microchannel utilizing a two-phase Eulerian-Eulerian model and including a steady state oxygen-hemoglobin reaction approximation
Analysis of low Reynolds number blood flow in a rectangular microchannel utilizing a two-phase Eulerian-Eulerian model and including a steady state oxygen-hemoglobin reaction approximation
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利用两相欧拉-欧拉模型并包括稳态氧-血红蛋白反应近似分析矩形微通道中的低雷诺数血流
DOI：
10.4208/aamm.2014.m538
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发表时间：
2009
影响因子：
1.4
通讯作者：
Jamie L. Wright
中科院分区：
文献类型：
--
作者：
Jamie L. Wright
红细胞（RBC）是非常重要的，因为它们的氧气运输从肺部的作用。随着疟原虫在疟疾感染的红细胞（IRBC）中生长，细胞的特性发生变化。在目前的工作中，由红细胞和IRBCs在肺毛细血管的氧摄取模拟使用的数值技术的基础上的二维浸没界面方法。静止的单个RBC的摄氧结果与先前报道的结果具有公平的协议。数值结果表明，疟疾感染可以显着地导致恶化的氧摄取的红细胞。实验结果还表明，当分离距离与细胞尺寸相当时，相邻细胞对单个静止RBC/IRBC的摄氧量影响不大。此外，它似乎是由红细胞和IRBC的氧摄取是由对流的质量扩散，虽然Peclet数是统一的顺序。
Red blood cells (RBCs) are very important due to their role of oxygen transport from lungs. As the malaria parasite grows in the malaria-infected red blood cells (IRBCs), the properties of the cells change. In the present work, the oxygen uptake by RBCs and IRBCs at the pulmonary capillaries is simulated using a numerical technique based on the two-dimensional immersed interface method. The results for the oxygen uptake by a stationary single RBC have fair agreements with the previously reported results. The numerical results show that the malaria infection could significantly cause deterioration on the oxygen uptake by red blood cells. The results also suggest that the oxygen uptake by individual stationary RBC/IRBC would not be significantly affected by the neighboring cells provided the separation distance is about the dimension of the cell. Furthermore, it appears that the oxygen uptake by both RBCs and IRBCs is dominated by mass diffusion over the convection although the Peclet number is of the order of unity.
影响因子：
3.4
作者：
CLARK, A;FEDERSPIEL, WJ;COKELET, GR
通讯作者：
COKELET, GR
影响因子：
3.3
作者：
Frank, AO;Chuong, CJC;Johnson, RL
通讯作者：
Johnson, RL
DOI：
10.1115/1.2112907
发表时间：
2005-12-01
影响因子：
1.7
作者：
Bagchi, P;Johnson, PC;Popel, AS
通讯作者：
Popel, AS