Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases.
Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases.
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DOI：
10.1111/pbi.13658
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发表时间：
2021-10
影响因子：
13.8
通讯作者：
Capell T
中科院分区：
文献类型：
--
作者：
He W;Baysal C;Lobato Gómez M;Huang X;Alvarez D;Zhu C;Armario-Najera V;Blanco Perera A;Cerda Bennaser P;Saba-Mayoral A;Sobrino-Mengual G;Vargheese A;Abranches R;Alexandra Abreu I;Balamurugan S;Bock R;Buyel JF;da Cunha NB;Daniell H;Faller R;Folgado A;Gowtham I;Häkkinen ST;Kumar S;Sathish Kumar R;Lacorte C;Lomonossoff GP;Luís IM;K-C Ma J;McDonald KA;Murad A;Nandi S;O'Keef B;Parthiban S;Paul MJ;Ponndorf D;Rech E;Rodrigues JCM;Ruf S;Schillberg S;Schwestka J;Shah PS;Singh R;Stoger E;Twyman RM;Varghese IP;Vianna GR;Webster G;Wilbers RHP;Christou P;Oksman-Caldentey KM;Capell T
防治传染病的斗争往往侧重于流行病和大流行病，这需要紧急资源，并引起卫生当局和媒体的关注。然而，传染病造成的死亡绝大多数发生在流行地区，特别是在发展中国家，给资金不足的卫生系统造成了不成比例的负担，往往需要国际干预。疫苗和其他生物制剂的提供不仅受到基于微生物和动物细胞的传统制造平台的高成本和有限的可扩展性的阻碍，而且还受到分销和储存造成的挑战，特别是在没有完整冷链的地区。在这篇综述文章中，我们考虑了分子农业在应对地方病和重新出现的疾病挑战方面的潜力，重点关注用于口服药物开发的可食用植物。该领域最近的关键进展包括基于口服黄花蒿干叶的成功临床试验，针对对青蒿素联合疗法耐药的疟疾寄生虫株，在叶子中生产临床级蛋白质药物以治疗传染病的能力，以及长期储存蛋白质药物在环境温度下的干叶中。最近FDA批准了第一种封装在植物细胞中的口服蛋白质药物，用于治疗花生过敏，这为开发负担得起的口服药物打开了大门，这些药物可以在没有冷藏基础设施的偏远地区生产和分销，并且消除了对昂贵的纯化步骤和注射无菌递送的需要。
The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re‐emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical‐grade protein drugs in leaves to treat infectious diseases and the long‐term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.
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