Autophagosome formation in relation to the endoplasmic reticulum.
Autophagosome formation in relation to the endoplasmic reticulum.
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DOI：
10.1186/s12929-020-00691-6
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发表时间：
2020-10-22
影响因子：
11
通讯作者：
Noda T
中科院分区：
文献类型：
--
作者：
Yamamoto YH;Noda T
自噬是一个过程，其中无数的膜结构称为自噬体在单个细胞中重新形成，将吞噬的底物递送到溶酶体中进行降解。自噬体的大小在非选择性自噬中是相对均匀的，而在选择性自噬中是可变的。最近已经确定，自噬体的形成发生在内质网（ER）附近。本文就自噬体的形成与内质网的关系作一综述。自噬体形成发生在富含磷脂合成酶如磷脂酰肌醇合酶（PIS）/CDP-二酰基甘油-肌醇3-磷脂酰转移酶（CDIPT）和胆碱/乙醇胺磷酸转移酶1（CEPT 1）的ER亚结构域附近。自噬相关蛋白2（Atg 2）参与自噬体的形成，具有脂质转移能力，被认为可以直接将脂质分子从内质网转移到自噬体中。内质网膜蛋白1（VMP 1）和跨膜蛋白41 b（TMEM 41 b）是与亚结构域形成相关的内质网膜蛋白。最近，我们报道了一种具有DNAJ结构域的未表征的ER膜蛋白，称为ERdj 8/DNAJC 16，与自噬体大小的调节有关。ERdj 8/DNAJC 16的定位与富含PIS的ER亚结构域部分重叠，从而暗示其与自噬体大小决定相关。
Autophagy is a process in which a myriad membrane structures called autophagosomes are formed de novo in a single cell, which deliver the engulfed substrates into lysosomes for degradation. The size of the autophagosomes is relatively uniform in non-selective autophagy and variable in selective autophagy. It has been recently established that autophagosome formation occurs near the endoplasmic reticulum (ER). In this review, we have discussed recent advances in the relationship between autophagosome formation and endoplasmic reticulum. Autophagosome formation occurs near the ER subdomain enriched with phospholipid synthesizing enzymes like phosphatidylinositol synthase (PIS)/CDP-diacylglycerol-inositol 3-phosphatidyltransferase (CDIPT) and choline/ethanolamine phosphotransferase 1 (CEPT1). Autophagy-related protein 2 (Atg2), which is involved in autophagosome formation has a lipid transfer capacity and is proposed to directly transfer the lipid molecules from the ER to form autophagosomes. Vacuole membrane protein 1 (VMP1) and transmembrane protein 41b (TMEM41b) are ER membrane proteins that are associated with the formation of the subdomain. Recently, we have reported that an uncharacterized ER membrane protein possessing the DNAJ domain, called ERdj8/DNAJC16, is associated with the regulation of the size of autophagosomes. The localization of ERdj8/DNAJC16 partially overlaps with the PIS-enriched ER subdomain, thereby implying its association with autophagosome size determination.
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DOI：
10.1083/jcb.201710116
发表时间：
2018-08-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gómez-Sánchez R;Rose J;Guimarães R;Mari M;Papinski D;Rieter E;Geerts WJ;Hardenberg R;Kraft C;Ungermann C;Reggiori F
通讯作者：
Reggiori F
影响因子：
7.7
作者：
Maeda, Shintaro;Otomo, Chinatsu;Otomo, Takanori
通讯作者：
Otomo, Takanori
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
21.3
作者：
Hayashi-Nishino, Mitsuko;Fujita, Naonobu;Yamamoto, Akitsugu
通讯作者：
Yamamoto, Akitsugu
影响因子：
13.3
作者：
Kobayashi, Shouhei;Kojidani, Tomoko;Haraguchi, Tokuko
通讯作者：
Haraguchi, Tokuko