Gender Differences in Patterns and Correlates of Continued Substance Use among Patients in Methadone Maintenance Treatment.
Gender Differences in Patterns and Correlates of Continued Substance Use among Patients in Methadone Maintenance Treatment.
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DOI：
10.1080/10826084.2021.1887242
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发表时间：
2021
影响因子：
2
通讯作者：
Polenick CA
中科院分区：
文献类型：
--
作者：
Arnold TD;Lin LA;Cotton BP;Bryson WC;Polenick CA
在阿片类药物使用障碍（OUD）治疗期间，持续使用药物是常见的。OUD患者持续使用药物和同时使用药物的模式因性别而异，这一点仍然不一致。关于美沙酮维持治疗（MMT）中男性和女性持续和同时使用美沙酮的相关因素可能有何不同，还有更多需要了解。这项横断面研究探讨了接受MMT的患者中同时使用药物亚组的预测因素。样本包括341名（n = 161名女性）年龄在18岁及以上的MMT患者，来自新英格兰南部和太平洋西北部的阿片类药物治疗项目。患者完成了一项评估社会人口统计学和临床特征的调查，包括上个月的药物使用情况。按性别进行潜在类别分析，以确定基于物质使用的群体，并确定这些类别的预测因子。三级解决方案对男性和女性都是最佳选择。对于两种性别，第一个亚组被描述为不太可能使用者（59.8%女性，52.8%男性）。妇女中的第二类和第三类是大麻/类阿片使用者（23.7%）和兴奋剂/类阿片使用者（13.0%）。在男性中，第二类和第三类包括酒精/大麻使用者（21.9%）和大麻/兴奋剂/阿片类使用者（25.3%）。曾经使用Suboxone（丁丙诺啡/纳洛酮）和抑郁/焦虑症状与女性物质使用组显着相关，而无家可归和就业状况与男性物质使用组显着相关。本研究进一步了解性别差异的因素与持续的物质使用和独特的模式，并发物质的使用，可能会指导量身定制的治疗患者MMT。
Continued substance use is common during opioid use disorder (OUD) treatment. There are still inconsistencies in how continued substance use and concurrent patterns of substance use among patients with OUD varies by gender. There is still more to learn regarding how factors associated with continued and concurrent use might differ for men and women in methadone maintenance treatment (MMT). This cross-sectional study examined predictors of concurrent substance use subgroups among patients receiving MMT. The sample included 341 (n = 161 women) MMT patients aged 18 and older from opioid treatment programs in Southern New England and the Pacific Northwest. Patients completed a survey assessing sociodemographic and clinical characteristics including past-month substance use. Latent class analyses were conducted by gender to identify groups based on substance use and determine predictors of those classes. Three-class solutions were the optimal fit for both men and women. For both genders, the first subgroup was characterized as Unlikely Users (59.8% women, 52.8% men). Classes 2 and 3 among women were Cannabis/Opioid Users (23.7%) and Stimulant/Opioid Users (13.0%). Among men, Classes 2 and 3 consisted of Alcohol/Cannabis Users (21.9%) and Cannabis/Stimulant/Opioid Users (25.3%). Ever using Suboxone (buprenorphine/naloxone) and depression/anxiety symptoms were significantly linked to substance use group among women, whereas homelessness and employment status were significantly associated with substance use group among men. This study furthers understanding of gender differences in factors associated with continued substance use and distinctive patterns of concurrent substance use that may guide tailored treatments among patients MMT.
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