Mice lacking paternal expression of imprinted Grb10 are risk-takers.
Mice lacking paternal expression of imprinted Grb10 are risk-takers.
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DOI：
10.1111/gbb.12679
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发表时间：
2020-09
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影响因子：
--
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中科院分区：
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印记基因Grb10和Nesp以相反的方式影响延迟折扣任务中的冲动行为。最近发展的一项理论表明，这种行为模式可能代表了印记基因对风险耐受性的预测效果。在这里，我们研究了缺乏父系Grb10表达的小鼠是否在一些表明冒险行为的指标上表现出异常行为。虽然Grb10+/p小鼠与野生型(WT)小鼠在探索新环境的意愿上没有差异，但它们在一项明确的冒险测试--捕食者气味冒险任务--上的行为表明它们冒险意愿增强。后续测试表明，这种冒险行为不仅仅是因为恐惧普遍减少，或者食物奖励的动机普遍增强，而是反映了成本和回报之间权衡的变化。这些数据，再加上之前关于Grb10+/p小鼠在延迟强化任务中的冲动行为的工作，以及我们在缺乏母体Nesp的小鼠上的工作，表明母系和父系表达的印记基因与预测的相反影响冒险行为。缺乏父亲印记Grb10的小鼠表现出更大的冒险行为。
The imprinted genes Grb10 and Nesp influence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of imprinted genes on tolerance to risk. Here we examine whether mice lacking paternal expression of Grb10 show abnormal behavior across a number of measures indicative of risk‐taking. Although Grb10 +/p mice show no difference from wild type (WT) littermates in their willingness to explore a novel environment, their behavior on an explicit test of risk‐taking, namely the Predator Odor Risk‐Taking task, is indicative of an increased willingness to take risks. Follow‐up tests suggest that this risk‐taking is not simply because of a general decrease in fear, or a general increase in motivation for a food reward, but reflects a change in the trade‐off between cost and reward. These data, coupled with previous work on the impulsive behavior of Grb10 +/p mice in the delayed reinforcement task, and taken together with our work on mice lacking maternal Nesp, suggest that maternally and paternally expressed imprinted genes oppositely influence risk‐taking behavior as predicted. Mice lacking paternal imprinted Grb10 show greater risk‐taking behavior.
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DOI：
10.1111/j.1749-6632.2000.tb06621.x
发表时间：
2000-01-01
期刊：
EVOLUTIONARY PERSPECTIVES ON HUMAN REPRODUCTIVE BEHAVIOR
影响因子：
--
作者：
Haig, D
通讯作者：
Haig, D
影响因子：
2.5
作者：
Dent, C. L.;Humby, T.;Isles, A. R.
通讯作者：
Isles, A. R.
影响因子：
25
作者：
Blomeley C;Garau C;Burdakov D
通讯作者：
Burdakov D
影响因子：
3.4
作者：
Humby, T;Laird, FM;Wilkinson, LS
通讯作者：
Wilkinson, LS
影响因子：
5.3
作者：
Schneider, Miriam;Kasanetz, Fernando;Spanagel, Rainer
通讯作者：
Spanagel, Rainer