Mycobacterium tuberculosis and Mycobacterium africanum in stools from children attending an immunization clinic in Ibadan, Nigeria.
Mycobacterium tuberculosis and Mycobacterium africanum in stools from children attending an immunization clinic in Ibadan, Nigeria.
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DOI：
10.1016/j.ijid.2008.11.016
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发表时间：
2009-11
影响因子：
8.4
通讯作者：
Taiwo, B. O.
中科院分区：
文献类型：
--
作者：
Cadmus, S. I. B.;Jenkins, A. O.;Godfroid, J.;Osinusi, K.;Adewole, I. F.;Murphy, R. L.;Taiwo, B. O.
结核病是尼日利亚儿童发病率和死亡率的主要原因。儿童结核病的诊断是一项全球性的挑战，使早期治疗成为一种幻想。我们调查了尼日利亚一家大型大学诊所提供的出生后3天至3岁儿童的粪便样本，进行Ziehl-Neelsen染色，以了解儿童粪便中分支杆菌的存在。对抗酸杆菌标本进一步进行分枝杆菌培养、球蛋白分型和缺失分型。采集192份不同儿童的粪便标本进行处理。30株(15.6%)有抗酸杆菌。在这些人中，8/30患有结核分枝杆菌，1/30患有非洲支原体。在看似健康的儿童中，约有5%(9/192)有证据表明可能存在严重的结核病感染。粪便标本对诊断儿童结核病的有用性值得进一步研究。
Tuberculosis is a major cause of childhood morbidity and mortality in Nigeria. Diagnosis of childhood tuberculosis is a global challenge making early treatment a mirage. We investigated the stool of children for the presence of mycobacteria Stool samples from children aged 3 days to 3 years who presented for postnatal immunization at a large university-based clinic in Nigeria were subjected to Ziehl-Neelsen staining. Samples with acid-fast bacilli were further processed using mycobacterial culture, spoligotyping and deletion typing. 192 stool samples from different children were collected and processed. Thirty (15.6%) had acid-fast bacilli. Of these, 8/30 had Mycobacterium tuberculosis and 1/30 had M. africanum. About 5 percent (9/192) of apparently well children had evidence of potentially serious tuberculosis infection. The usefulness of stool specimens for diagnosing pediatric tuberculosis warrants further investigation.
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影响因子：
120.7
作者：
Dye, C;Scheele, S;Raviglione, RC
通讯作者：
Raviglione, RC
影响因子：
9.4
作者：
Niobe-Eyangoh, SN;Kuaban, C;Gutierrez, MC
通讯作者：
Gutierrez, MC
影响因子：
9.4
作者：
Kamerbeek, J;Schouls, L;vanEmbden, J
通讯作者：
vanEmbden, J
影响因子：
28.2
作者：
Mwachari, C;Batchelor, BIF;Gilks, CF
通讯作者：
Gilks, CF
DOI：
10.1073/pnas.052548299
发表时间：
2002-03-19
影响因子：
11.1
作者：
Brosch, R;Gordon, SV;Cole, ST
通讯作者：
Cole, ST