Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration.
Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration.
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DOI：
10.1007/s00441-016-2431-9
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发表时间：
2016-09
影响因子：
3.6
通讯作者：
Ruskoaho, Heikki
中科院分区：
文献类型：
--
作者：
Talman, Virpi;Ruskoaho, Heikki
关键词：
心肌梗死期间的缺血性细胞死亡导致多相修复反应，其中受损组织被成纤维细胞和肌成纤维细胞产生的纤维化瘢痕替代。这也诱导未损伤的心室壁的几何、生物力学和生化变化，引发包括间质和血管周围纤维化的反应性重塑过程。虽然最初的修复性纤维化对于防止心室壁破裂至关重要，但损伤区域外的过度纤维化反应和反应性纤维化是有害的，因为它们导致心脏功能的进行性损害并最终导致心力衰竭。在这篇综述中，我们总结了目前的知识，修复性和反应性心肌纤维化的机制，在应对心肌梗死，讨论通过直接重编程成纤维细胞和肌成纤维细胞到心肌细胞诱导心脏再生的潜力，并审查目前可用的和潜在的未来的治疗策略，以抑制心脏纤维化。心肌梗死后的修复反应。缺氧诱导的心肌细胞死亡导致肌成纤维细胞的激活和损伤区域的修复性纤维化反应。右上图在成年哺乳动物中，梗死区域形成的纤维化瘢痕是永久性的，并促进未受损心肌的反应性纤维化。右下图在硬骨鱼和蝾螈以及胚胎和新生哺乳动物中，纤维化疤痕的初始形成之后是心肌组织的再生。诱导成年哺乳动物梗死后心脏再生是目前深入研究和药物发现尝试的目标
Ischemic cell death during a myocardial infarction leads to a multiphase reparative response in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and myofibroblasts. This also induces geometrical, biomechanical, and biochemical changes in the uninjured ventricular wall eliciting a reactive remodeling process that includes interstitial and perivascular fibrosis. Although the initial reparative fibrosis is crucial for preventing rupture of the ventricular wall, an exaggerated fibrotic response and reactive fibrosis outside the injured area are detrimental as they lead to progressive impairment of cardiac function and eventually to heart failure. In this review, we summarize current knowledge of the mechanisms of both reparative and reactive cardiac fibrosis in response to myocardial infarction, discuss the potential of inducing cardiac regeneration through direct reprogramming of fibroblasts and myofibroblasts into cardiomyocytes, and review the currently available and potential future therapeutic strategies to inhibit cardiac fibrosis. Reparative response following a myocardial infarction. Hypoxia-induced cardiomyocyte death leads to the activation of myofibroblasts and a reparative fibrotic response in the injured area. Right top In adult mammals, the fibrotic scar formed at the infarcted area is permanent and promotes reactive fibrosis in the uninjured myocardium. Right bottom In teleost fish and newts and in embryonic and neonatal mammals, the initial formation of a fibrotic scar is followed by regeneration of the cardiac muscle tissue. Induction of post-infarction cardiac regeneration in adult mammals is currently the target of intensive research and drug discovery attempts
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影响因子：
2.5
作者：
Dai, Zhehao;Fukumoto, Yoshihiro;Shimokawa, Hiroaki
通讯作者：
Shimokawa, Hiroaki
影响因子：
49.6
作者：
Bui, Anh L.;Horwich, Tamara B.;Fonarow, Gregg C.
通讯作者：
Fonarow, Gregg C.
影响因子：
20.1
作者：
Dobaczewski M;Bujak M;Li N;Gonzalez-Quesada C;Mendoza LH;Wang XF;Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
4
作者：
Srivastava, Deepak;Berry, Emily C.
通讯作者：
Berry, Emily C.
DOI：
10.1016/j.bbadis.2010.07.003
发表时间：
2011-01-01
影响因子：
6.2
作者：
Aranguiz-Urroz, Pablo;Canales, Jimena;Diaz-Araya, Guillermo
通讯作者：
Diaz-Araya, Guillermo