Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary.
Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary.
复制标题
DOI：
10.1007/s11357-021-00470-7
复制
发表时间：
2022-03
期刊：
影响因子：
5.6
通讯作者：
Kovács T
中科院分区：
文献类型：
--
作者：
Balázs N;Bereczki D;Ajtay A;Oberfrank F;Kovács T
痴呆症是导致老年人口死亡和残疾的主要原因之一。以前的报告表明，抗痴呆症药物与更长的生存期有关；尽管如此，它们的使用率和依从性在世界各地都有很大不同。关于这些药物在东欧地区的药物流行病学，几乎没有任何可用的信息；我们的目标是分析胆碱酯酶抑制剂(ChEIs)用于治疗痴呆症的使用情况，以提供东欧地区的真实信息。对2013年至2016年期间在匈牙利NeUROHUN数据库中收集的所有住院和门诊专家服务的医疗和药物处方报告进行了分析。计算存活率、依从性和持续值。8803例患者在研究期间接受了CHEIs治疗，仅占确诊痴呆患者的14.5%。接受CHEI治疗的患者生存期(4年以上)明显长于未接受CHEI治疗的患者(2.50年)。利瓦斯明贴片的依从性最好。在痴呆症确诊后尽快选择合适的药物可能会延长预期寿命。
Dementia is one of the leading causes of death and disability in older population. Previous reports have shown that antidementia medications are associated with longer survival; nonetheless, the prevalence of their use and the compliance with them are quite different worldwide. There is hardly any available information about the pharmacoepidemiology of these drugs in the Eastern-European region; we aimed to analyze the use of cholinesterase inhibitors (ChEis) for the treatment of dementia to provide real-life information from the Eastern European region. All medical and medication prescription reports of the in- and outpatient specialist services collected in the NEUROHUN database in Hungary were analyzed between 2013 and 2016. Survival, adherence, and persistence values were calculated. 8803 patients were treated with ChEis during the study period, which was only 14.5% of the diagnosed demented patients. The survival of treated patients (more than 4 years) was significantly longer than patients without ChEi treatment (2.50 years). The best compliance was observed with rivastigmine patch. Choosing the appropriate medication as soon as possible after the dementia diagnosis may lead to increased life expectancy.
登录
查看更多内容
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
--
作者：
Saletu B;Garg A;Shoeb A
通讯作者：
Shoeb A
影响因子：
6.3
作者：
Koller D;Hua T;Bynum JP
通讯作者：
Bynum JP
影响因子：
5
作者：
Zhang YS;Li JD;Yan C
通讯作者：
Yan C
影响因子：
120.7
作者：
Benner, JS;Glynn, RJ;Avorn, J
通讯作者：
Avorn, J