Retinoids: present role and future potential.
Retinoids: present role and future potential.
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DOI：
10.1038/sj.bjc.6690312
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发表时间：
1999-04
影响因子：
8.8
通讯作者：
Kaye, SB
中科院分区：
文献类型：
--
作者：
Evans, TRJ;Kaye, SB
维生素A及其生物活性衍生物、视黄酸和维甲酸(RA)，以及大量的合成类似物统称为维甲酸。自然产生的维甲酸调节多种细胞类型的生长和分化，在视觉生理学和胚胎发育期间作为形态发生因子发挥关键作用。维甲酸及其类似物已被评估为化学预防药物，并用于急性早幼粒细胞白血病的治疗。维甲酸主要通过与特定受体结合和调节基因表达来发挥作用。新的活性维甲酸的开发和两个不同的维甲酸受体家族的鉴定使人们对激活这些受体的细胞效应有了更多的了解。在这篇文章中，我们回顾了维甲酸在化学预防策略中的使用，讨论了激活的维甲酸受体的细胞后果，并推测我们对维甲酸诱导的信号通路的理解如何有助于未来在恶性疾病管理中的治疗策略。©1999癌症研究活动
Vitamin A and its biologically active derivatives, retinal and retinoic acid (RA), together with a large repertoire of synthetic analogues are collectively referred to as retinoids. Naturally occurring retinoids regulate the growth and differentiation of a wide variety of cell types and play a crucial role in the physiology of vision and as morphogenic agents during embryonic development. Retinoids and their analogues have been evaluated as chemoprevention agents, and also in the management of acute promyelocytic leukaemia. Retinoids exert most of their effects by binding to specific receptors and modulating gene expression. The development of new active retinoids and the identification of two distinct families of retinoid receptors has led to an increased understanding of the cellular effects of activation of these receptors. In this article we review the use of retinoids in chemoprevention strategies, discuss the cellular consequences of activated retinoid receptors, and speculate on how our increasing understanding of retinoid-induced signalling pathways may contribute to future therapeutic strategies in the management of malignant disease. © 1999 Cancer Research Campaign
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影响因子：
64.5
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作者：
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