Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy.
Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy.
复制标题
扩张型心肌病患者左心室心房钠尿多肽的分泌增加。
DOI：
10.1172/jci113883
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
H. Imura
中科院分区：
文献类型：
--
作者：
Hirofumi Yasue;K. Obata;Ken Okumura;M. Kurose;Hisao Ogawa;K. Matsuyama;M. Jougasaki;Yoshihiko Saito;K. Nakao;H. Imura
为探讨扩张型心肌病（DCM）患者左心室是否有心钠素（ANP）释放，我们测定了11例DCM患者和18例对照组主动脉根（Ao）、前室间静脉（AIV）、心大静脉（GCV）和冠状窦（CS）血浆ANP水平。Ao、AIV、GCV和CS的血浆ANP水平分别为454 +/- 360、915 +/- 584、1，308 +/- 926和1，884 +/-1，194 pg/ml，DCM患者分别为108 +/- 42、127 +/- 55、461 +/- 224和682 +/- 341 pg/ml，分别在对照组中。对照组Ao与AIV之间血浆ANP水平无显著性差异。相反，DCM患者血浆ANP水平在Ao和AIV之间显著升高（P <0.001）。因此，与对照组相比，DCM患者Ao和AIV之间的ANP水平差异显著增加（461 +/- 248 vs. 19 +/- 59 pg/ml，P <0.001）。与对照组相比，DCM患者Ao和CS之间的ANP水平差异也显著增加（1，429 +/- 890 vs. 577 +/- 318 pg/ml，P <0.001）。我们的结论是心钠素释放到循环中的增加量从左心室以及从心脏作为一个整体在DCM患者。
To examine whether atrial natriuretic polypeptide (ANP) is released from the left ventricle in patients with dilated cardiomyopathy (DCM) we measured plasma ANP level in the aortic root (Ao), the anterior interventricular vein (AIV), the great cardiac vein (GCV), and the coronary sinus (CS) in 11 patients with DCM and 18 control subjects. Plasma ANP levels in Ao, AIV, GCV, and CS were 454 +/- 360, 915 +/- 584, 1,308 +/- 926, and 1,884 +/- 1,194 pg/ml, respectively, in the patients with DCM and 108 +/- 42, 127 +/- 55, 461 +/- 224, and 682 +/- 341 pg/ml, respectively, in the control subjects. There was no significant difference in the plasma ANP levels between Ao and AIV in the control subjects. On the contrary, there was a significant (P less than 0.001) step-up in plasma ANP levels between Ao and AIV in patients with DCM. Thus, the difference in ANP levels between Ao and AIV was significantly increased in patients with DCM as compared with the control subjects (461 +/- 248 vs. 19 +/- 59 pg/ml, P less than 0.001). The difference in ANP levels between Ao and CS was also significantly increased in patients with DCM as compared with the control subjects (1,429 +/- 890 vs. 577 +/- 318 pg/ml, P less than 0.001). We conclude that ANP is released in increased amounts into the circulation from the left ventricle as well as from the heart as a whole in patients with DCM.
心房钠尿激素、肾素-醛固酮轴和血压-电解质稳态。
DOI：
10.1056/nejm198511213132106
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Laragh,JH
通讯作者：
Laragh,JH
DOI：
10.1073/pnas.83.18.6697
发表时间：
1986-09-01
影响因子：
11.1
作者：
GARDNER, DG;DESCHEPPER, CF;LEWICKI, J
通讯作者：
LEWICKI, J